Acute Hospital Mortality of Venous Thromboembolism in Patients With Cancer From Registry Data

• Material Type: 博士論文
• ISSN: 2047-9980
• Title: Acute Hospital Mortality of Venous Thromboembolism in Patients With Cancer From Registry Data
• Volume: 10 11
• Author/Editor: Okushi, Yuichiro; Kusunose, Kenya; Okayama, Yoshihiro; Zheng, Robert; Nakai, Michikazu; Sumita, Yoko; Ise, Takayuki; Tobiume, Takeshi; Yamaguchi, Koji; Yagi, Shusuke; Fukuda, Daiju; Yamada, Hirotsugu; Soeki, Takeshi; Wakatsuki, Tetsuzo; Sata, Masataka
• Author Heading: Okushi, Yuichiro; Kusunose, Kenya; Okayama, Yoshihiro; Zheng, Robert; Nakai, Michikazu; Sumita, Yoko; Ise, Takayuki; Tobiume, Takeshi; Yamaguchi, Koji; Yagi, Shusuke; Fukuda, Daiju; Yamada, Hirotsugu; Soeki, Takeshi; Wakatsuki, Tetsuzo; Sata, Masataka
• Publication, Distribution, etc.: The American Heart Association
• Publication Date: 2021-05-22
• Publication Date (W3CDTF): 2021-05-22
• Alternative Title: レジストリデータによるがん患者の静脈血栓塞栓症の急性期死亡率; Thromboembolism and Cancer
• Periodical title: Journal of the American Heart Association
• Degree grantor/type: 徳島大学
• Date Granted: 2021-07-29
• Date Granted (W3CDTF): 2021-07-29
• Dissertation Number: 甲第3531号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3531号
• Text Language Code: eng
• Subject Heading: cardio-oncology; mortality; venous thromboembolism; Big data
• Target Audience: 一般
• Note (General): BACKGROUND: The prognosis of patients with cancer-venous thromboembolism (VTE) is not well known because of a lack of registry data. Moreover, there is also no knowledge on how specific types are related to prognosis. We sought to evaluate the clinical characteristics and outcomes of patients with cancer-associated VTE, compared with a matched cohort without cancer using real-world registry data of VTE.METHODS AND RESULTS: This study was based on the Diagnosis Procedure Combination database in the JROAD-DPC (Japanese Registry of All Cardiac and Vascular Diseases and the Diagnosis Procedure Combination). Of 5 106 151 total patients included in JROAD-DPC, we identified 49 580 patients who were first hospitalized with VTE from April 2012 to March 2017. Propensity score was estimated with a logistic regression model, with cancer as the dependent variable and 18 clinically relevant covariates. After propensity matching, there were 25 148 patients with VTE with or without cancer. On propensity score-matched analysis with 25 148 patients with VTE, patients with cancer had higher total in-hospital mortality within 7 days (1.3% versus 1.1%, odds ratio [OR], 1.66; 95% CI, 1.31–2.11; P<0.0001), 14 days (2.5% versus 1.5%, OR, 2.07; 95% CI, 1.72–2.49; P<0.0001), and 30 days (4.8% versus 2.0%, OR, 2.85; 95% CI, 2.45–3.31; P<0.0001). On analysis for each type of cancer, in-hospital mortality in 11 types of cancer was significantly high, especially pancreas (OR, 12.96; 95% CI, 6.41–26.20), biliary tract (OR, 8.67; 95% CI, 3.00–25.03), and liver (OR, 7.31; 95% CI, 3.05–17.50).CONCLUSIONS: Patients with cancer had a higher in-hospital acute mortality for VTE than those without cancer, especially in pancreatic, biliary tract, and liver cancers.
• DOI: info:doi/10.1161/JAHA.120.019373; https://doi.org/info:doi/10.1161/JAHA.120.019373
• Persistent ID (NDL): info:ndljp/pid/11711096; https://dl.ndl.go.jp/pid/11711096
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-08-09T17:15:52+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/116140
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp