Usefulness of a finger-mounted tissue oximeter with near-infrared spectroscopy for evaluating the intestinal oxygenation and viability in rats

• Material Type: 博士論文
• ISSN: 0941-1291
• Title: Usefulness of a finger-mounted tissue oximeter with near-infrared spectroscopy for evaluating the intestinal oxygenation and viability in rats
• Volume: 51 6
• Author/Editor: 鈴木, 雄飛
• Author Heading: 鈴木, 雄飛
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2021-06
• Publication Date (W3CDTF): 2021-06
• Alternative Title: 指装着型組織オキシメーターを用いた近赤外線分光法によるラット腸管の酸素化および生存能評価の有用性
• Periodical title: Surgery Today
• Degree grantor/type: 浜松医科大学
• Date Granted: 2021-03-16
• Date Granted (W3CDTF): 2021-03-16
• Dissertation Number: 甲第873号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第873号
• Text Language Code: eng
• Subject Heading: Rat; Intestine; Ischemia reperfusion; Near-infrared spectroscopy
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Purpose To investigate the utility of the device for evaluating intestinal oxygenation and viability using an animal model.Methods Sprague?Dawley rats underwent laparotomy under general anesthesia, and the blood vessels in the terminal ileum were clamped to create ischemia. We measured the regional tissue oxygenation saturation (rSO2) using an oximeter after 1, 3, and 6 h of vessel clamping. Ischemic tissue damage was assessed using a histological score. The intestine was reperfused after each clamping period, and intestinal rSO2 and survival rate were evaluated.Results When reperfusion was performed at 1 and 3 h after ischemia, rSO2 increased after 10 min, and it improved to the same level as for normal intestine after 1 h; all rats survived for 1 week. In contrast, after 6 h of ischemia, rSO2 did not increase after reperfusion, and all animals died within 2 days. The histological scores increased after 1 h of reperfusion, with longer clamping periods.Conclusion A finger-mounted tissue oximeter could evaluate intestinal ischemia and the viability, which is thus considered to be a promising result for future clinical application.
• DOI: info:doi/10.1007/s00595-020-02171-8; https://doi.org/info:doi/10.1007/s00595-020-02171-8
• Persistent ID (NDL): info:ndljp/pid/11720304; https://dl.ndl.go.jp/pid/11720304
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-09-06T03:11:00+09:00
• Date Created (W3CDTF): 2021-07-20
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003877; https://hama-med.repo.nii.ac.jp/records/3751
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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