A Pilot Study Investigating the Use of Regional Oxygen Saturation as a Predictor of Ischemic Wound Healing Outcome after Endovascular Treatment in Patients with Chronic Limb-Threatening Ischemia

• Material Type: 博士論文
• ISSN: 1881-641X
• Title: A Pilot Study Investigating the Use of Regional Oxygen Saturation as a Predictor of Ischemic Wound Healing Outcome after Endovascular Treatment in Patients with Chronic Limb-Threatening Ischemia
• Volume: 14 1
• Author/Editor: 嘉山, 貴文
• Author Heading: 嘉山, 貴文
• Publication, Distribution, etc.: The Editorial Committee of Annals of Vascular Diseases
• Publication Date: 2021-03-25
• Publication Date (W3CDTF): 2021-03-25
• Alternative Title: 重症下肢虚血患者に対する血管内治療後、組織酸素濃度測定値の潰瘍治癒予後予測の有用性についてのパイロット研究
• Periodical title: Annals of Vascular Diseases
• Degree grantor/type: 浜松医科大学
• Date Granted: 2021-03-16
• Date Granted (W3CDTF): 2021-03-16
• Dissertation Number: 甲第860号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第860号
• Text Language Code: eng
• Subject Heading: pilot study; oximetry; near-infrared spectroscopy; ischemia; wound healing
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Objective: To determine the prognostic value of regional tissue oxygenation saturation (rSO2) for ulcer healing after endovascular treatment (EVT) of peripheral arterial disease (PAD).Materials and Methods: Among PAD patients, 34 patients with chronic limb-threatening ischemia underwent EVT for limb salvage. We retrospectively analyzed the cutoff rSO2 values on postoperative day 1 to predict ulcer healing and patient prognosis. Skin perfusion pressure (SPP) and transcutaneous oxygen pressure (TcPO2) were also used to assess wound healing.Results: A finger-mounted tissue oximeter can easily measure rSO2 on the dorsal foot. Among the 34 patients, the ulcer healed in 25, and no changes were observed in 2 patients at 1 month after EVT. However, 7 patients needed major amputation at the same time. Wound healing was achieved in all patients with rSO2 ≥50%. With this cutoff, the sensitivity and specificity of the new device for wound healing were 100% and 64%, respectively. In all the wound healing cases, SPP was ≥45mmHg, and TcPO2 was ≥40mmHg.Conclusion: To assess limb ischemia, rSO2 can be measured quickly and easily using this device. We suggest that an rSO2 >50% shows good prognosis for ulcer healing.
• DOI: info:doi/10.3400/avd.oa.20-00132; https://doi.org/info:doi/10.3400/avd.oa.20-00132
• Persistent ID (NDL): info:ndljp/pid/11720307; https://dl.ndl.go.jp/pid/11720307
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-09-06T03:11:00+09:00
• Date Created (W3CDTF): 2021-07-20
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003870; https://hama-med.repo.nii.ac.jp/records/3744
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp