Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain

• Material Type: 博士論文
• ISSN: 2045-2322
• Title: Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain
• Volume: 10
• Author/Editor: 衞藤, 史博
• Author Heading: 衞藤, 史博
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2020-05-04
• Publication Date (W3CDTF): 2020-05-04
• Alternative Title: マウス脳におけるグルタミン酸及びγ-アミノ酪酸量に対するScrapperの領域特異的な効果
• Periodical title: Scientific Reports
• Degree grantor/type: 浜松医科大学
• Date Granted: 2021-03-16
• Date Granted (W3CDTF): 2021-03-16
• Dissertation Number: 甲第866号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第866号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; The brain consists of various areas with anatomical features. Neurons communicate with one another via excitatory or inhibitory synaptic transmission. Altered abundance of neurotransmitters, including glutamate and gamma-aminobutyric acid (GABA), in specific brain regions is closely involved in severe neurological diseases, such as schizophrenia and obsessive-compulsive disorder. SCRAPPER, a ubiquitin E3 ligase, regulates synaptic transmission. Scrapper gene deficiency results in defective neurotransmission due to excessive secretion of neurotransmitters. The present study employed matrix-assisted laser desorption/ionization imaging mass spectrometry to analyze the abundance of amino acid neurotransmitters in Scrapper knockout (SCR-KO) mice. SCR-KO mice exhibited significantly increased glutamate levels in the isocortex (CTX), corpus callosum (CC), thalamus (TH), midbrain (MB), cerebellar cortex (CBX), and caudoputamen (CP) and increased GABA levels in the CTX, CC, TH, MB, CBX and hypothalamus (HY) compared with wild-type mice. These findings indicate that Scrapper deficiency leads to upregulated glutamate and GABA levels in multiple regions. Our results show a differential, region-specific effect of Scrapper on the abundance of glutamate and GABA.
• DOI: info:doi/10.1038/s41598-020-64277-w; https://doi.org/info:doi/10.1038/s41598-020-64277-w
• Persistent ID (NDL): info:ndljp/pid/11720311; https://dl.ndl.go.jp/pid/11720311
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-09-06T03:11:00+09:00
• Date Created (W3CDTF): 2021-07-20
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003874; https://hama-med.repo.nii.ac.jp/records/3748
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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