Daikenchuto increases blood flow in the superior mesenteric artery in humans: A comparison study between four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction magnetic resonance imaging and Doppler ultrasound

• Material Type: 博士論文
• ISSN: 1932-6203
• Title: Daikenchuto increases blood flow in the superior mesenteric artery in humans: A comparison study between four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction magnetic resonance imaging and Doppler ultrasound
• Volume: 16 1
• Author/Editor: 鈴木, 克徳
• Author Heading: 鈴木, 克徳
• Publication, Distribution, etc.: Public Library of Science (PLoS)
• Publication Date: 2021-01-27
• Publication Date (W3CDTF): 2021-01-27
• Alternative Title: 大建中湯はヒト上腸間膜動脈の血流を増加させる: 4D PC-VIPRと超音波の比較検討試験
• Periodical title: PLOS ONE
• Degree grantor/type: 浜松医科大学
• Date Granted: 2021-03-16
• Date Granted (W3CDTF): 2021-03-16
• Dissertation Number: 甲第871号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第871号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Respiratory-gated four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction (4D PC-VIPR) is magnetic resonance (MR) imaging technique that enables analysis of vascular morphology and hemodynamics in a single examination using cardiac phase resolved 3D phase-contrast magnetic resonance imaging. The present study aimed to assess the usefulness of 4D PC-VIPR for the superior mesenteric artery (SMA) flowmetry before and after flow increase was induced by the herbal medicine Daikenchuto (TJ-100) by comparing it with Doppler ultrasound (DUS) as a current standard. Twenty healthy volunteers were enrolled in this prospective single-arm study. The peak cross-sectionally averaged velocity was measured by 4D PC-VIPR, peak velocity was measured by DUS, and flow volume (FV) of SMA and aorta were measured by 4D PC-VIPR and DUS 25 min before and after the peroral administration of TJ-100. The peak cross-sectionally averaged velocity, peak velocity, and FV of SMA measured by 4D PC-VIPR and DUS significantly increased after administration of TJ-100 (4D PC-VIPR: the peak cross-sectionally averaged velocity; p=0.004, FV; p=0.035, DUS: the peak velocity; p=0.003, FV; p=0.010). Furthermore, 4D PC-VIPR can analyze multiple blood vessels simultaneously. The ratio of the SMA FV to the aorta, before and after oral administration on the 4D PC-VIPR test also increased (p=0.015). The rate of change assessed by 4D PC-VIPR and DUS were significantly correlated (the peak cross-sectionally averaged velocity and peak velocity: r=0.650; p=0.005, FV: r=0.659; p=0.004). Retrospective 4D PC-VIPR was a useful modality for morphological and hemodynamic analysis of SMA.
• DOI: info:doi/10.1371/journal.pone.0245878; https://doi.org/info:doi/10.1371/journal.pone.0245878
• Persistent ID (NDL): info:ndljp/pid/11720313; https://dl.ndl.go.jp/pid/11720313
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-09-06T03:11:00+09:00
• Date Created (W3CDTF): 2021-07-20
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003876; https://hama-med.repo.nii.ac.jp/records/3750
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2023-09-02 再収集

2023-10-11 再収集

2023-12-15 再収集