Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma

• Material Type: 博士論文
• ISSN: 1687-4757
• Title: Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma
• Volume: 2019
• Author/Editor: Tatsuya, Morinishi; Yasunori, Tokuhara; Hiroyuki, Ohsaki; Emi, Ibuki; Kyuichi, Kadota; Eiichiro, Hirakawa
• Publication Date: 2019-07-03
• Publication Date (W3CDTF): 2019-07-03
• Periodical title: PPAR Research
• Degree grantor/type: 香川県立保健医療大学
• Date Granted: 2020-03-10
• Date Granted (W3CDTF): 2020-03-10
• Dissertation Number: 甲第1号
• Degree Type: 博士（臨床検査学）
• Conferring No. (Dissertation): 甲第1号
• Text Language Code: eng
• Subject Heading: PPAR-α; 大腸癌; アポトーシス
• NDC: 493.465
• Note (General): Peroxisome proliferator-activated receptor alpha (PPAR-α) belongs to the PPAR family and plays a critical role in inhibiting cell proliferation and tumorigenesis in various tumors. However, the role of PPAR-α in colorectal tumorigenesis is unclear. In the present study, we found that fenofibrate, a PPAR-α agonist, significantly inhibited cell proliferation and induced apoptosis in colorectal carcinoma cells. In addition, PPAR-α was expressed in the nucleus of colorectal carcinoma cells, and the expression of nuclear PPAR-α increased in colorectal carcinoma tissue compared with that of normal epithelium tissue (P<0.01). The correlation between the expression of nuclear PPAR-α and clinicopathological factors was evaluated in human colorectal carcinoma tissues, and the nuclear expression of PPAR-α was significantly higher in well-to-moderately differentiated adenocarcinoma than in mucinous adenocarcinoma (P<0.05). These findings indicate that activation of PPAR-α may be involved in anticancer effects in colorectal carcinomas, and nuclear expression of PPAR-α may be a therapeutic target for colorectal adenocarcinoma treatment.; PubMed番号 : 31354797; NII論文ID : 120006709588; 元資料の権利情報 : open access; 元資料の権利情報 : Copyright © 2019 Tatsuya Morinishi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.; 元資料の権利情報 : Copyright © 2019 Tatsuya Morinishi et al. This is an open access article distributed under the Creative Commons AttributionLicense, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properlycited.; 開始ページ : 1; 終了ページ : 9
• DOI: info:doi/10.50850/00000330; https://doi.org/info:doi/10.50850/00000330
• Persistent ID (NDL): info:ndljp/pid/11766063; https://dl.ndl.go.jp/pid/11766063
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• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-10-05T14:27:03+09:00
• Date Created (W3CDTF): 2021-09-02
• Format (IMT): application/pdf
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• Original Material (URI): https://kagawa-puhs.repo.nii.ac.jp/?action=pages_view_main&active_action=repository_view_main_item_detail&item_id=336&item_no=1&page_id=13&block_id=21
• Periodical Title (URI): http://id.nii.ac.jp/1751/00000330/
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp