Lack of functional MHC class Ⅰ leads to altered dopamine system and ADHD-like behavior in mice

• Material Type: 博士論文
• Title: Lack of functional MHC class Ⅰ leads to altered dopamine system and ADHD-like behavior in mice
• Author/Editor: 孟, 紅蕊
• Author Heading: 孟, 紅蕊
• Publication Date: 2013-09-20
• Publication Date (W3CDTF): 2013-09-20
• Alternative Title: マウスにおけるMHCクラスⅠの機能阻害はドーパミン系を変化させADHD様行動を惹起する
• Degree grantor/type: 浜松医科大学
• Date Granted: 2013-09-20
• Date Granted (W3CDTF): 2013-09-20
• Dissertation Number: 甲第663号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第663号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; application/pdf; Midbrain dopamine systems play a crucial role in the regulation of many behavioral processes and their abnormalities underlie the development of several psychiatric diseases such as attention deficit hyperactivity disorder (ADHD), autism and schizophrenia. These systems express the major histocompatibility complex class I (MHCI), a neuro-immune molecule recently identified to be present in the neurons and glial cells of the brain. The MHCI molecules regulate neural connectivity and plasticity in the developing as well as adult brain. Here we report that mice in which functional MHCI has been lacked exhibit hyperactivity, motor impulsiveness and attention deficits that are three major symptoms of ADHD. They also show alterations in the gene expression of dopamine synthetic enzyme, transporter and receptor subtypes in the cell body and terminal areas of the midbrain dopamine systems. Moreover, their behavioral phenotypes are improved, although not completely reversed, by methylphenidate, an ADHD medicine. These results indicate important behavioral functions for the MHCI molecules within the brain and suggest novel therapeutic targets for ADHD and other psychiatric disorders related to the malfunctions of midbrain dopamine systems.
• Persistent ID (NDL): info:ndljp/pid/11864260; https://dl.ndl.go.jp/pid/11864260
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-11-08T14:10:24+09:00
• Date Created (W3CDTF): 2018-08-27
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/2770; https://hama-med.repo.nii.ac.jp/records/2642
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2023-09-02 再収集

2023-10-11 再収集