Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic-ischemic insult in newborn piglets

The cover of this title could differ from library to library.

Available in National Diet Library

Find on the publisher's website

国立国会図書館デジタルコレクション

Digital data available

Check on the publisher's website

DOI[info:doi/10.1038/s41598-021-92586-1]to the data of the same series

Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic-ischemic insult in newborn piglets

Persistent ID (NDL): info:ndljp/pid/11864293

Material type: 博士論文

Author: 光家, 努

Publisher: -

Publication date: 2021-09-28

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 香川大学,博士（医学）

View All

Notes on use at the National Diet Library

本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。

Notes on use

Note (General)：: Neonatal hypoxic–ischemic encephalopathy is a notable cause of neonatal death and developmental disabilities. To achieve better outcomes, it is import...

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
Title: Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic-ischemic insult in newborn piglets
Author/Editor: 光家, 努
Author Heading: 光家, 努
Publication Date: 2021-09-28
Publication Date (W3CDTF): 2021-09-28
Alternative Title: 新生仔豚低酸素性虚血性モデルにおいて近赤外光時間分解分光法を用いた蘇生後の脳血液量の増加は負荷の程度を推定することが可能である
Degree grantor/type: 香川大学
Date Granted: 2021-09-28
Date Granted (W3CDTF): 2021-09-28
Dissertation Number: 甲第783号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第783号
Text Language Code: eng
Alias of Author: Mitsuie, Tsutomu
Subject Heading: Biomarkers
Diseases
Neurology
Target Audience: 一般
Note (General): Neonatal hypoxic–ischemic encephalopathy is a notable cause of neonatal death and developmental disabilities. To achieve better outcomes, it is important in treatment strategy selection to categorize the degree of hypoxia ischemia and evaluate dose response. In an asphyxia piglet model with histopathological brain injuries that we previously developed, animals survived 5 days after insult and showed changes in cerebral blood volume (CBV) that reflected the severity of injuries. However, little is known about the relationship between changes in CBV during and after insult. In this study, an HI event was induced by varying the amount and timing of inspired oxygen in 20 anesthetized piglets. CBV was measured using near-infrared time-resolved spectroscopy before, during, and 6 h after insult. Change in CBV was calculated as the difference between the peak CBV value during insult and the value at the end of insult. The decrease in CBV during insult was found to correlate with the increase in CBV within 6 h after insult. Heart rate exhibited a similar tendency to CBV, but blood pressure did not. Because the decrement in CBV was larger in severe HI, the CBV increment immediately after insult is considered useful for assessing degree of HI insult.
DOI: info:doi/10.1038/s41598-021-92586-1
https://doi.org/info:doi/10.1038/s41598-021-92586-1
Persistent ID (NDL): info:ndljp/pid/11864293
https://dl.ndl.go.jp/pid/11864293
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2021-11-08T14:10:24+09:00
Date Created (W3CDTF): 2021-10-05
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/7842
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp