Low-Intensity Pulsed Ultrasound Ameliorates Neuropathic Pain Induced by Partial Sciatic Nerve Ligation Via Regulating Macrophage Polarization 34 1

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Low-Intensity Pulsed Ultrasound Ameliorates Neuropathic Pain Induced by Partial Sciatic Nerve Ligation Via Regulating Macrophage Polarization

Persistent ID (NDL): info:ndljp/pid/11864506

Material type: 博士論文

Author: Liu, Yaoほか

Publisher: 四国歯学会

Publication date: 2021-09-08

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（歯学）

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Note (General)：: Inflammatory (M1-polarized) macrophages cause neuropathic pain (NP) after nerve injury through non-resolving neuroinflammation. However, increasing ev...

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Material Type: 博士論文
ISSN: 2189-6682
Title: Low-Intensity Pulsed Ultrasound Ameliorates Neuropathic Pain Induced by Partial Sciatic Nerve Ligation Via Regulating Macrophage Polarization
Volume: 34 1
Author/Editor: Liu, Yao
Xia, Linze
Kano, Fumiya
Hashimoto, Noboru
Matsuka, Yoshizo
Yamamoto, Akihito
Tanaka, Eiji
Author Heading: Liu, Yao
Xia, Linze
Kano, Fumiya
Hashimoto, Noboru
Matsuka, Yoshizo
Yamamoto, Akihito
Tanaka, Eiji
Publication, Distribution, etc.: 四国歯学会
Publication Date: 2021-09-08
Publication Date (W3CDTF): 2021-09-08
Alternative Title: 低出力超音波パルスは坐骨神経部分結紮によって引き起こされる神経障害性疼痛をマクロファージ極性制御を介して改善する
Ultrasound Ameliorates Neuropathic Pain
Periodical title: Journal of Oral Health and Biosciences
Degree grantor/type: 徳島大学
Date Granted: 2021-09-09
Date Granted (W3CDTF): 2021-09-09
Dissertation Number: 甲第3543号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第3543号
Text Language Code: eng
Subject Heading: Neuropathic pain
Low-intensity pulsed ultrasound
Macrophages
Anti-inflammation
Target Audience: 一般
Note (General): Inflammatory (M1-polarized) macrophages cause neuropathic pain (NP) after nerve injury through non-resolving neuroinflammation. However, increasing evidence suggests that converting M1 to anti-inflammatory M2 macrophages may rescue NP. In the present study, the therapeutic potential of low-intensity pulsed ultrasound (LIPUS) was investigated in a partial sciatic nerve ligation (PSL)-induced NP model.Materials and Methods: Abnormal pain sensation, such as tactile allodynia, was caused by PSL. Immediately after PSL induction, the mice were subjected to LIPUS treatment for 20 min/day for 7 days. LIPUS was used at an average intensity of 60 mW/cm2 and a frequency of 1.5 MHz.Results: In the behavioral test, the LIPUS group showed a significant improvement in the PSL-induced hypersensitivity compared to the PSL group not exposed to LIPUS. We found an increasing number of M2 macrophages in the injured sciatic nerves after LIPUS exposure. LIPUS treatment decreased expression of pro-inflammatory microglial markers in spinal cord.Conclusions: Our data suggest that LIPUS has an anti-nociceptive effect by increasing anti-inflammatory M2 macrophage and may be a suitable therapeutic candidate for NP.
DOI: info:doi/10.20738/johb.34.1_11
https://doi.org/info:doi/10.20738/johb.34.1_11
Persistent ID (NDL): info:ndljp/pid/11864506
https://dl.ndl.go.jp/pid/11864506
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2021-11-08T14:10:24+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/116287
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp