Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice

• Material Type: 博士論文
• ISSN: 2045-2322
• Title: Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
• Volume: 11
• Author/Editor: Dalanon, Junhel Casinillo; Chikahisa, Sachiko; Shiuchi, Tetsuya; Shimizu, Noriyuki; Chavan, Parimal; Suzuki, Yoshitaka; Okura, Kazuo; Séi, Hiroyoshi; Matsuka, Yoshizo
• Author Heading: Dalanon, Junhel Casinillo; Chikahisa, Sachiko; Shiuchi, Tetsuya; Shimizu, Noriyuki; Chavan, Parimal; Suzuki, Yoshitaka; Okura, Kazuo; Séi, Hiroyoshi; Matsuka, Yoshizo
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2021-07-09
• Publication Date (W3CDTF): 2021-07-09
• Alternative Title: 軽度な慢性ストレスはマウスの睡眠を障害し疼痛感受性を増大させる
• Periodical title: Scientific Reports
• Degree grantor/type: 徳島大学
• Date Granted: 2021-09-09
• Date Granted (W3CDTF): 2021-09-09
• Dissertation Number: 甲第3542号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第3542号
• Text Language Code: eng
• Subject Heading: Hyperalgesia; Predictable chronic mild stress; Sleep; Slow-wave activity; Interleukin-6; Tumor necrosis factor-alpha
• Target Audience: 一般
• Note (General): Even though it has been well documented that stress can lead to the development of sleep disorders and the intensification of pain, their relationships have not been fully understood. The present study was aimed at investigating the effects of predictable chronic mild stress (PCMS) on sleep–wake states and pain threshold, using the PCMS rearing conditions of mesh wire (MW) and water (W) for 21 days. Exposure to PCMS decreased the amount of non-rapid eye movement (NREM) sleep during the dark phase. Moreover, the chronicity of PCMS decreased slow-wave activity (SWA) during NREM sleep in the MW and W groups in both the light and dark phases. Mechanical and aversively hot thermal hyperalgesia were more intensified in the PCMS groups than the control. Higher plasma corticosterone levels were seen in mice subjected to PCMS, whereas TNF-α expression was found higher in the hypothalamus in the W and the trigeminal ganglion in the MW group. The W group had higher expression levels of IL-6 in the thalamus as well. The PCMS paradigm decreased SWA and may have intensified mechanical and thermal hyperalgesia. The current study also suggests that rearing under PCMS may cause impaired sleep quality and heightened pain sensation to painful mechanical and aversively hot thermal stimuli.
• DOI: info:doi/10.1038/s41598-021-93560-7; https://doi.org/info:doi/10.1038/s41598-021-93560-7
• Persistent ID (NDL): info:ndljp/pid/11864508; https://dl.ndl.go.jp/pid/11864508
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-11-08T14:10:24+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/116125
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp