Establishment of a pigmented murine model abundant with characteristics of retinal vein occlusion

• Material Type: 博士論文
• ISSN: 0014-4835
• Title: Establishment of a pigmented murine model abundant with characteristics of retinal vein occlusion
• Volume: 204
• Author/Editor: 宮城, 清弦
• Author Heading: 宮城, 清弦
• Publication, Distribution, etc.: Elsevier Ltd.
• Publication Date: 2021-06-02
• Publication Date (W3CDTF): 2021-06-02
• Alternative Title: ヒト臨床所見に合致した眼底像を呈する有色マウス網膜静脈閉塞症モデルの確立
• Periodical title: Experimental Eye Research
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2021-06-02
• Date Granted (W3CDTF): 2021-06-02
• Dissertation Number: 甲医歯薬第1348号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医歯薬第1348号
• Text Language Code: eng
• Subject Heading: Murine model; Retina; Retinal vein occlusion; VEGF
• Target Audience: 一般
• Note (General): Retinal vein occlusion (RVO) is a vascular disease that represents characteristic retinal hemorrhage and dilated retinal veins. Despite its clinical importance, its pathogenesis remains largely unknown because of limited opportunities to acquire human retinal samples. Therefore, an animal model that reproduces the clinical features of RVO patients is required for further investigation. In this study, we established a pigmented murine RVO model that reproduced characteristic fundus appearances similar to human RVO findings. Retinal edema in this model was observed in both optical coherence tomography and histological analysis, which is a clinically important outcome. With quantitative real-time PCR analysis on retinal samples, we revealed that the mRNA level of vascular endothelial growth factor (VEGF) increased in the retina induced RVO. Moreover, this retinal edema was reduced by intravitreal injection of anti-VEGF antibody. These results were consistent with human clinical knowledge and suggested that this model could be a useful tool for research into new therapeutic approaches.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1348号 学位授与年月日:令和3年6月2日; Author: Sugao Miyagi, Anri Nishinaka, Takumi Yamamoto, Wataru Otsu, Shinsuke Nakamura, Masamitsu Shimazawa, Takashi Kitaoka, Hideaki Hara; Citation: Experimental Eye Research, 204, 108441; 2021; identifier:Nagasaki University (長崎大学), 博士(医学) (2021-06-02); http://hdl.handle.net/10069/00040831
• DOI: info:doi/10.1016/j.exer.2021.108441; https://doi.org/info:doi/10.1016/j.exer.2021.108441
• Persistent ID (NDL): info:ndljp/pid/11929666; https://dl.ndl.go.jp/pid/11929666
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-12-07T08:33:55+09:00
• Date Created (W3CDTF): 2021-07-01
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://hdl.handle.net/10069/00040831
• Periodical Title (URI): http://hdl.handle.net/10069/00040846
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp