Irisin supports integrin-mediated cell adhesion of lymphocytes

Persistent ID (NDL): info:ndljp/pid/11976677

Material type: 博士論文

Author: Myint, Phyoe Kyawe

Publisher: 三重大学

Publication date: 2021-09-15

Material Format: Digital

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Name of awarding university/degree: 三重大学,博士(医学)

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Note (General)：: application/pdfIrisin, a myokine released from skeletal muscle, has recently been found to act as a ligand for the integrins αVβ5, αVβ1, and α5β1 expr...

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Material Type: 博士論文
Title: Irisin supports integrin-mediated cell adhesion of lymphocytes
Author/Editor: Myint, Phyoe Kyawe
Author Heading: Myint, Phyoe Kyawe
Publication, Distribution, etc.: 三重大学
Publication Date: 2021-09-15
Publication Date (W3CDTF): 2021-09-15
Degree grantor/type: 三重大学
Date Granted: 2021-09-15
Date Granted (W3CDTF): 2021-09-15
Dissertation Number: 甲医学第2086号
Degree Type: 博士(医学)
Conferring No. (Dissertation): 甲医学第2086号
Text Language Code: eng
Subject Heading: Integrins
Cell adhesion
Irisin
Fibronectin type III domain-containing protein 5
Target Audience: 一般
Note (General): application/pdf
Irisin, a myokine released from skeletal muscle, has recently been found to act as a ligand for the integrins αVβ5, αVβ1, and α5β1 expressed on mesenchymal cells, thereby playing an important role in the metabolic remodeling of the bone, skeletal muscle and adipose tissues. Although the immune-modulatory effects of irisin in chronic inflammation have been documented, its interactions with lymphocytic integrins have yet to be elucidated. Here, we show that irisin supports the cell adhesion of human and mouse lymphocytes. Cell adhesion assays using a panel of inhibitory antibodies to integrins have shown that irisin-mediated lymphocyte adhesion involves multiple integrins including not only α4β1 and α5β1, but also leukocyte-specific αLβ2 and α4β7. Importantly, mouse lymphocytic TK-1 cells that lack the expression of β1 integrins have exhibited αLβ2- and α4β7-mediated cell adhesion to irisin. Irisin has also been demonstrated to bind to purified recombinant integrin αLβ2 and α4β7 proteins. Thus, irisin represents a novel ligand for integrin αLβ2 and α4β7, capable of supporting lymphocyte cell adhesion independently of β1 integrins. These results suggest that irisin may play an important role in regulating lymphocyte adhesion and migration in the inflamed vasculature.
本文/Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Japan
8p
DOI: info:doi/10.1016/j.bbrep.2021.100977
https://doi.org/info:doi/10.1016/j.bbrep.2021.100977
Persistent ID (NDL): info:ndljp/pid/11976677
https://dl.ndl.go.jp/pid/11976677
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-01-10T16:22:37+09:00
Date Created (W3CDTF): 2022-01-04
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10076/00020070
https://mie-u.repo.nii.ac.jp/records/14452
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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