The value of serum uric acid as a prognostic biomarker in amyotrophic lateral sclerosis : Evidence from a meta-analysis

• Material Type: 博士論文
• ISSN: 0303-8467
• Title: The value of serum uric acid as a prognostic biomarker in amyotrophic lateral sclerosis : Evidence from a meta-analysis
• Volume: 203
• Author/Editor: Haji, Shotaro; Sako, Wataru; Murakami, Nagahisa; Osaki, Yusuke; Furukawa, Takahiro; Izumi, Yuishin; Kaji, Ryuji
• Author Heading: Haji, Shotaro; Sako, Wataru; Murakami, Nagahisa; Osaki, Yusuke; Furukawa, Takahiro; Izumi, Yuishin; Kaji, Ryuji
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2021-02-19
• Publication Date (W3CDTF): 2021-02-19
• Alternative Title: 筋萎縮性側索硬化症の予後バイオマーカーとしての血清尿酸値の有用性 : メタアナリシスからのエビデンス
• Periodical title: Clinical Neurology and Neurosurgery
• Degree grantor/type: 徳島大学
• Date Granted: 2021-12-23
• Date Granted (W3CDTF): 2021-12-23
• Dissertation Number: 甲第3566号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3566号
• Text Language Code: eng
• Subject Heading: Amyotrophic lateral sclerosis; Uric acid; Hazard ratio; Meta-analysis; Survival
• Target Audience: 一般
• Note (General): Objective: To determine the value of uric acid (UA) as a prognostic biomarker for amyotrophic lateral sclerosis (ALS) using a meta-analysis of hazard ratio-based studies.Methods: We included data from Tokushima University (47 patients with ALS) and three previous studies (1835 patients with ALS) with a hazard ratio (HR) identified by a systematic computational search. A total of four studies and 1882 patients were enrolled in the pooled analysis. We pooled HRs of death or tracheostomy, which were estimated by a Cox proportional hazard model, using a random-effects model. Heterogeneity was assessed by Q statistic, and a p value < 0.1 was considered significant heterogeneity. Furthermore, sensitivity analysis was performed to assess the effect of each single study and the robustness of the summary effect. We evaluated publication bias by visual assessment of the funnel plot and Egger’s test, and adjusted the bias using a trim-and-fill method.Results: This meta-analysis revealed that UA could be a prognostic factor for ALS (all, HR = 0.87, p < 0.001; men, HR = 0.83, p < 0.001; women, HR = 0.76, p < 0.001). The included studies were homogeneous (all, p = 0.43; men, p = 0.9; women, p = 0.49). Sensitivity analysis confirmed the robustness of these summary effects. Publication bias was detected, which was adjusted for by a trim-and-fill method. The adjusted results showed significant summary effects (all, HR = 0.88, p = 0.002; men, HR = 0.83, p < 0.001; women, HR = 0.77, p < 0.001).Conclusion: The present meta-analysis suggests that the serum UA level could be a prognostic biomarker in patients with ALS. Sensitivity analyses and the trim-and-fill method supported the robustness of these results.
• DOI: info:doi/10.1016/j.clineuro.2021.106566; https://doi.org/info:doi/10.1016/j.clineuro.2021.106566
• Persistent ID (NDL): info:ndljp/pid/11976684; https://dl.ndl.go.jp/pid/11976684
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-01-10T16:22:37+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/116650
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp