Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma （頭頸部扁平上皮癌におけるPLAC1の発現およびPLAC1特異的ヘルパーT細胞の抗腫瘍効果に関する研究） 10 1

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Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma （頭頸部扁平上皮癌におけるPLAC1の発現およびPLAC1特異的ヘルパーT細胞の抗腫瘍効果に関する研究） 1

Persistent ID (NDL): info:ndljp/pid/11976846

Material type: 博士論文

Author: 林, 隆介

Publisher: -

Publication date: 2020-12

Material Format: Digital

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Name of awarding university/degree: 旭川医科大学,博士（医学）

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Note (General)：: Placenta-specific 1 (PLAC1) is expressed primarily in placental trophoblasts but not in normal tissues and is a targetable candidate for cancer immuno...

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Material Type: 博士論文
ISSN: 2162-4011
Title: Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma （頭頸部扁平上皮癌におけるPLAC1の発現およびPLAC1特異的ヘルパーT細胞の抗腫瘍効果に関する研究）
Volume: 10 1
Author/Editor: 林, 隆介
Publication Date: 2020-12
Publication Date (W3CDTF): 2020-12
Periodical title: Oncoimmunology
Degree grantor/type: 旭川医科大学
Date Granted: 2021-03-25
Date Granted (W3CDTF): 2021-03-25
Dissertation Number: 甲第560号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第560号
Text Language Code: eng
Subject Heading: CD4 T cells
PLAC1
Placenta-specific 1
epitope
head and neck squamous cell carcinoma
helper T lymphocytes
immunotherapy
peptide vaccine
Note (General): Placenta-specific 1 (PLAC1) is expressed primarily in placental trophoblasts but not in normal tissues and is a targetable candidate for cancer immunotherapy because it is a cancer testis antigen known to be up-regulated in various tumors. Although peptide epitopes capable of stimulating CD8 T cells have been previously described, there have been no reports of PLAC1 CD4 helper T lymphocyte (HTL) epitopes and the expression of this antigen in head and neck squamous cell carcinoma (HNSCC). Here, we show that PLAC1 is highly expressed in 74.5% of oropharyngeal and 51.9% of oral cavity tumors from HNSCC patients and in several HNSCC established cell lines. We also identified an HTL peptide epitope (PLAC131-50) capable of eliciting effective antigen-specific and tumor-reactive T cell responses. Notably, this peptide behaves as a promiscuous epitope capable of stimulating T cells in the context of more than one human leukocyte antigen (HLA)-DR allele and induces PLAC1-specific CD4 T cells that kill PLAC1-positive HNSCC cell lines in an HLA-DR-restricted manner. Furthermore, T-cells reactive to PLAC131-50 peptide were detected in the peripheral blood of HNSCC patients. These findings suggest that PLAC1 represents a potential target antigen for HTL based immunotherapy in HNSCC.
identifier:PMID:33457076
開始ページ : 1856545
DOI: info:doi/10.1080/2162402X.2020.1856545
https://doi.org/info:doi/10.1080/2162402X.2020.1856545
Persistent ID (NDL): info:ndljp/pid/11976846
https://dl.ndl.go.jp/pid/11976846
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-01-10T16:22:37+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20210325_K560
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp