Changes in the pharmacokinetics of teicoplanin in patients with hyperglycaemic hypoalbuminaemia: Impact of albumin glycosylation on the binding of teicoplanin to albumin

• Material Type: 博士論文
• Title: Changes in the pharmacokinetics of teicoplanin in patients with hyperglycaemic hypoalbuminaemia: Impact of albumin glycosylation on the binding of teicoplanin to albumin
• Author/Editor: Enokiya, Tomoyuki
• Author Heading: Enokiya, Tomoyuki
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2015-12-16
• Publication Date (W3CDTF): 2015-12-16
• Degree grantor/type: 三重大学
• Date Granted: 2015-12-16
• Date Granted (W3CDTF): 2015-12-16
• Dissertation Number: 乙医学第991号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 乙医学第991号
• Text Language Code: eng
• Alias of Author: エノキヤ, トモユキ; 榎屋, 友幸
• Subject Heading: Teicoplanin; Hyperglycaemia; Hypoalbuminaemia; Albumin binding; Glycosylated albumin
• Target Audience: 一般
• Note (General): application/pdf; There is large interindividual variability in serum teicoplanin (TEIC) concentrations after administration of a loading dose, and the factors that influence the pharmacokinetics of TEIC are disputed. The aim of this study was to clarify changes in the pharmacokinetics of TEIC that occur in patients with hyperglycaemia as well as the impact of albumin glycosylation on the pharmacokinetics of TEIC. This study consisted of retrospective and prospective investigations. The pharmacokinetic parameters of TEIC were retrospectively compared between patients receiving TEIC treatment. Ninety-four patients were divided into four groups according to their serum albumin and blood glucose concentrations [(i) hyperglycaemic hypoalbuminaemia (albumin < 3.0 g/dL) (n= 16); (ii) non-hyperglycaemic hypoalbuminaemia (n=29); (iii) hyperglycaemic normoalbuminaemia (albumin≥3.0 g/dL) (n=9); and (iv) non-hyperglycaemic normoalbuminaemia(n=40)]. In addition, the concentration of glycosylated albumin was prospectivelydetermined in 28 patients. At 12h after administration of a loading dose, patients with hyperglycaemic hypoalbuminaemia displayed significantly lower serum TEIC concentrations (P< 0.05) and higher TEIC volume of distribution (Vd) (P <0.05) than the other three groups, whereas TEIC clearance did not differ significantly among the groups. In addition, the percentage of glycosylated albumin was significantly correlated with the association constant (Ka) of TEIC for albumin (r=0.53, P=0.004) and the Vd (r=0.41, P=0.031). These results suggest that hyperglycaemic hypoalbuminaemia lowers the serum TEIC concentration, which is attributable to the decreased Ka and increased Vd of TEIC by albumin glycosylation.; 本文/Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University, 2-174 Edobashi, Tsu 514-8507, Mie, Japan; 5p
• DOI: info:doi/10.1016/j.ijantimicag.2015.03.010; https://doi.org/info:doi/10.1016/j.ijantimicag.2015.03.010
• Persistent ID (NDL): info:ndljp/pid/11976969; https://dl.ndl.go.jp/pid/11976969
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-01-10T16:22:37+09:00
• Date Created (W3CDTF): 2021-12-13
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00020056; https://mie-u.repo.nii.ac.jp/records/14438
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp