Elevated plasma levels of soluble platelet glycoprotein VI (GPVI) in patients with thrombotic microangiopathy

Persistent ID (NDL): info:ndljp/pid/11976971

Material type: 博士論文

Author: Yamashita, Yoshiki

Publisher: 三重大学

Publication date: 2014-12-10

Material Format: Digital

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Name of awarding university/degree: 三重大学,博士(医学)

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Note (General)：: application/pdfBackground: Thrombotic microangiopathy (TMA) is caused by various conditions, such as decreased a ADAMTS13 level, activated or injured ...

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Material Type: 博士論文
Title: Elevated plasma levels of soluble platelet glycoprotein VI (GPVI) in patients with thrombotic microangiopathy
Author/Editor: Yamashita, Yoshiki
Author Heading: Yamashita, Yoshiki
Publication, Distribution, etc.: 三重大学
Publication Date: 2014-12-10
Publication Date (W3CDTF): 2014-12-10
Degree grantor/type: 三重大学
Date Granted: 2014-12-10
Date Granted (W3CDTF): 2014-12-10
Dissertation Number: 乙医学第975号
Degree Type: 博士(医学)
Conferring No. (Dissertation): 乙医学第975号
Text Language Code: eng
Alias of Author: ヤマシタ, ヨシキ
山下, 芳樹
Subject Heading: TMA
Platelet activation
ADAMTS13
sGPVI
Target Audience: 一般
Note (General): application/pdf
Background: Thrombotic microangiopathy (TMA) is caused by various conditions, such as decreased a ADAMTS13 level, activated or injured vascular endothelial cells or activated platelets. This study examined the soluble platelet glycoprotein VI (sGPVI) levels in patients with TMA to evaluate the activation of platelets in thrombotic states. Materials and methods: The plasma levels of sGPVI, ADAMTS13 activity, von Willebrand factor (VWF) and VWF propeptide (VWFpp) were measured in patients with TMA. Results: The plasma levels of sGPVI were significantly higher in postoperative patients, patients with TMA and those with disseminated intravascular coagulation (DIC) than in those without thrombosis. The plasma levels of sGPVI were the highest in patients with TMA without markedly reduced ADAMTS13 and those were significantly reduced after plasma exchange. Conclusion: The measurement of sGPVI level is therefore considered to be important for the diagnosis and evaluation of TMA.
本文/Departments of Hematology and Oncology, Mie University Hospital and Mie University Graduate School of Medicine, Tsu, Japan
5p
DOI: info:doi/10.1016/j.thromres.2013.11.023
https://doi.org/info:doi/10.1016/j.thromres.2013.11.023
Persistent ID (NDL): info:ndljp/pid/11976971
https://dl.ndl.go.jp/pid/11976971
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-01-10T16:22:37+09:00
Date Created (W3CDTF): 2021-12-13
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10076/00020050
https://mie-u.repo.nii.ac.jp/records/14432
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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