Intravenous edaravone plus therapeutic hypothermia offers limited neuroprotection in the hypoxic-ischaemic newborn piglet

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Intravenous edaravone plus therapeutic hypothermia offers limited neuroprotection in the hypoxic-ischaemic newborn piglet

Persistent ID (NDL): info:ndljp/pid/11977395

Material type: 博士論文

Author: 山戸, 聡史

Publisher: -

Publication date: 2020-12-24

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: Background: Therapeutic hypothermia (TH) is a standard therapy for neonatal hypoxic-ischaemic encephalopathy. One potential additional therapy is the ...

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Material Type: 博士論文
Title: Intravenous edaravone plus therapeutic hypothermia offers limited neuroprotection in the hypoxic-ischaemic newborn piglet
Author/Editor: 山戸, 聡史
Author Heading: 山戸, 聡史
Publication Date: 2020-12-24
Publication Date (W3CDTF): 2020-12-24
Alternative Title: 新生子豚低酸素虚血モデルにおける低体温療法とエダラボン静脈内投与の併用療法の神経保護効果は限定的だった
Degree grantor/type: 香川大学
Date Granted: 2020-12-24
Date Granted (W3CDTF): 2020-12-24
Dissertation Number: 甲第763号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第763号
Text Language Code: eng
Alias of Author: Yamato, Satoshi
Subject Heading: Edaravone
Hypoxic-ischemic encephalopathy
Piglet
Therapeutic hypothermia
Target Audience: 一般
Note (General): Background: Therapeutic hypothermia (TH) is a standard therapy for neonatal hypoxic-ischaemic encephalopathy. One potential additional therapy is the free radical scavenger edaravone (EV; 3-methyl-1-phenyl-2-pyrazolin-5-one).
Objectives and Methods: This study aimed to compare the neuroprotective effects of edaravone plus therapeutic hypothermia (TH + EV) with those of TH alone after a hypoxic-ischaemic insult in the newborn piglet. Anaesthetized piglets were subjected to 40 min of hypoxia (3–5% inspired oxygen), and cerebral ischaemia was assessed using cerebral blood volume. Body temperature was maintained at 39.0 ± 0.5°C in the normothermia group (NT, n = 8) and at 33.5 ± 0.5°C (24 h after the insult) in the TH (n = 7) and TH + EV (3 mg/kg intravenous every 12 h for 3 days after the insult; n = 6) groups under mechanical ventilation.
Results: Five days after the insult, the mean (standard deviation) neurological scores were 10.9 (5.7) in the NT group, 17.0 (0.4) in the TH group (p = 0.025 vs. NT), and 15.0 (3.9) in the TH + EV group. The histopathological score of the TH + EV group showed no significant improvement compared with that of the other groups.
Conclusion: TH + EV had no additive neuroprotective effects after hypoxia-ischaemia in neurological and histopathological assessments.
DOI: info:doi/10.1159/000511085
https://doi.org/info:doi/10.1159/000511085
Persistent ID (NDL): info:ndljp/pid/11977395
https://dl.ndl.go.jp/pid/11977395
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-01-10T16:22:37+09:00
Date Created (W3CDTF): 2021-02-03
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/7188
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp