Alternative Titleラット凍結肩モデルを用いた経カテーテル的動脈塞栓術の効果に関する検討
Periodical titleJournal of vascular and interventional radiology
Note (General)type:Thesis
Purpose: To assess the angiographic findings and the effects of transcatheter arterial embolization on physical activity and histopathology using a frozen shoulder rat model. Materials and methods: First, the angiographic and histopathologic findings of rats in which the shoulder was immobilized with molding plaster for 6 weeks (n = 4) were compared to control rats with normal non-immobilized shoulders (n = 4). Next, a total of 16 frozen shoulder rats were divided into 2 groups. In the transcatheter arterial embolization group (n = 8), imipenem/cilastatin was injected into the left thoracoacromial artery. The changes of physical activity before and after procedures were evaluated and compared with a saline-injected control group (n = 8). Histopathologic findings were also compared between the 2 groups. Results: Angiography revealed abnormal shoulder staining in all of the rats with a frozen shoulder. On histopathology, the numbers of microvessels and mononuclear inflammatory cells in the synovial membrane of the joint capsule were significantly higher compared with the control rats (both P = .03). In the transcatheter arterial embolization group, the running distance and speed were improved (P = .03 and P = .01, respectively), whereas there were no significant differences in the control group. The number of microvessels and mononuclear inflammatory cells in the transcatheter arterial embolization group were significantly lower than the control group (P = .002 and P = .001, respectively). Conclusions: The rat frozen shoulder model revealed the development of neovascularization. Transcatheter arterial embolization decreased the number of blood vessels and inflammatory changes in the frozen shoulder and increased the moving distance and speed of the rats.
博士（医学）・甲第789号・令和3年3月15日
Copyright © 2020 SIR(Society of Interventional Radiology). Published by Elsevier Inc. All rights reserved.
identifier:Journal of vascular and interventional radiology Vol.32 No.3 p.376-383 (2021 Mar)
identifier:10510443
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3913
identifier:Journal of vascular and interventional radiology, 32(3): 376-383
DOIinfo:doi/10.1016/j.jvir.2020.10.017
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2022-02-06T04:33:19+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション