Enhanced Osseointegration and Bio-Decontamination of Nanostructured Titanium Based on Non-Thermal Atmospheric Pressure Plasma

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Enhanced Osseointegration and Bio-Decontamination of Nanostructured Titanium Based on Non-Thermal Atmospheric Pressure Plasma

Persistent ID (NDL): info:ndljp/pid/12071383

Material type: 博士論文

Author: 曾, 昱豪

Publisher: -

Publication date: 2021-03-05

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Alkali-treated titanate layer with nanonetwork structures (TNS) is a promising surface for improving osseointegration capacity in implants. Neverthele...

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Material Type: 博士論文
Title: Enhanced Osseointegration and Bio-Decontamination of Nanostructured Titanium Based on Non-Thermal Atmospheric Pressure Plasma
Author/Editor: 曾, 昱豪
Author Heading: 曾, 昱豪
Publication Date: 2021-03-05
Publication Date (W3CDTF): 2021-03-05
Alternative Title: 非熱大気圧プラズマによるナノ構造析出純チタン金属上の強化されたオッセオインテグレーションとバイオ除染
Degree grantor/type: 大阪歯科大学
Date Granted: 2021-03-05
Date Granted (W3CDTF): 2021-03-05
Dissertation Number: 甲第914号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第914号
Text Language Code: eng
Subject Heading: osseointegration｜biofilm inhibition｜ non-thermal plasma treatment
Target Audience: 一般
Note (General): Alkali-treated titanate layer with nanonetwork structures (TNS) is a promising surface for improving osseointegration capacity in implants. Nevertheless, there is a risk of device failure as a result of insu_cient resistance to biofilm contamination. This study tested whether treatment using a handheld non-thermal plasma device could e_ciently eliminate biofilm contamination without destroying the surface nanostructure while re-establishing a surface that promoted new bone generation. TNS specimens were treated by a piezoelectric direct discharge (PDD) plasma generator.The evaluation of initial cell attachment with adhesion images, alkaline phosphatase activity, extracellular matrix mineralization, and expression of genes related to osteogenesis was performed using rat bone marrow mesenchymal stem cells, and the bone response were evaluated in vivo using a rat femur model. Nanotopography and surface roughness did not significantly di_er before and after plasma treatments. Cell and bone formation activity were improved by TNS plasma treatment. Furthermore, plasma treatment e_ectively eliminated biofilm contamination from the surface. These results suggested that this plasma treatment may be a promising approach for the treatment of nanomaterials immediately before implantation and a therapeutic strategy for peri-implantitis.
2020年度
Persistent ID (NDL): info:ndljp/pid/12071383
https://dl.ndl.go.jp/pid/12071383
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2021-04-23
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000281/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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