Effects of plasma treatment on the bioactivity of alkali-treated ceria-stabilised zirconia/alumina nanocomposite(NANOZR)

• Material Type: 博士論文
• Title: Effects of plasma treatment on the bioactivity of alkali-treated ceria-stabilised zirconia/alumina nanocomposite(NANOZR)
• Author/Editor: 高尾, 誠二
• Author Heading: 高尾, 誠二
• Publication Date: 2021-03-05
• Publication Date (W3CDTF): 2021-03-05
• Alternative Title: アルカリ処理したセリア安定型ジルコニア/アルミナナノ複合体（NANOZR）の生体適合性にプラズマ処理が与える影響
• Degree grantor/type: 大阪歯科大学
• Date Granted: 2021-03-05
• Date Granted (W3CDTF): 2021-03-05
• Dissertation Number: 甲第913号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第913号
• Text Language Code: eng
• Subject Heading: Ce-stabilised zirconia/alumina nanocomposite｜ plasma treatment｜implant｜ bone｜ surface roughness｜ superhydrophilicity
• Target Audience: 一般
• Note (General): Zirconia ceramics such as ceria-stabilized zirconia/alumina nanocomposites (nano-ZR) are applied as implant materials due to their excellent mechanical properties. However, surface treatment is required to obtain sufficient biocompatibility. In the present study, we explored the material surface functionalization and assessed the initial adhesion of rat bone marrow mesenchymal stem cells, their osteogenic differentiation, and production of hard tissue, on plasma-treated alkali-modified nano-ZR. Superhydrophilicity was observed on the plasma-treated surface of alkali-treated nano-ZR along with hydroxide formation and reduced surface carbon. A decreased contact angle was also observed as nano-ZR attained an appropriate wettability index. Treated samples showed higher in vitro bovine serum albumin (BSA) adsorption, initial adhesion of bone marrow and endothelial vascular cells, high alkaline phosphatase activity, and increased expression of bone differentiation-related factors. Furthermore, the in vivo performance of treated nano-ZR was evaluated by implantation in the femur of male Sprague–Dawley rats. The results showed that the amount of bone formed after the plasma treatment of alkali-modified nano-ZR was higher than that of untreated nano-ZR. Thus, induction of superhydrophilicity in nano-ZR via atmospheric pressure plasma treatment affects bone marrow and vascular cell adhesion and promotes bone formation without altering other surface properties.; 2020年度
• Persistent ID (NDL): info:ndljp/pid/12071384; https://dl.ndl.go.jp/pid/12071384
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
• Date Created (W3CDTF): 2021-04-23
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://id.nii.ac.jp/1392/00000280/
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-09-08 再収集