Development of an assay to determine expression levels of ERBB2 and SIRT1 mRNA in saliva

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Development of an assay to determine expression levels of ERBB2 and SIRT1 mRNA in saliva

Persistent ID (NDL): info:ndljp/pid/12071388

Material type: 博士論文

Author: 山本, 慎

Publisher: -

Publication date: 2021-03-05

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: The diagnosis of lifestyle-related diseases and cancer at an early stage is important. The use of saliva, rather than blood testing, for diagnosis has...

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Material Type: 博士論文
Title: Development of an assay to determine expression levels of ERBB2 and SIRT1 mRNA in saliva
Author/Editor: 山本, 慎
Author Heading: 山本, 慎
Publication Date: 2021-03-05
Publication Date (W3CDTF): 2021-03-05
Alternative Title: 唾液を用いたERBB2およびSIRT1 mRNAの発現レベルを決定するアッセイの開発
Degree grantor/type: 大阪歯科大学
Date Granted: 2021-03-05
Date Granted (W3CDTF): 2021-03-05
Dissertation Number: 甲第909号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第909号
Text Language Code: eng
Subject Heading: ERBB2｜SIRT1｜mRNA saliva ｜blood
Target Audience: 一般
Note (General): The diagnosis of lifestyle-related diseases and cancer at an early stage is important. The use of saliva, rather than blood testing, for diagnosis has many advantages, especially in terms of its non-invasiveness and convenience. we assessed expression levels of ERBB2, a cancer-related gene, and SIRT1, a gene associated with suppressing aging and improving immunity, using human saliva rather than blood samples. Fasting blood samples and unstimulated saliva samples from passive drooling were collected from healthy volunteers in their twenties, and the levels of markers within each sample were assessed via real-time polymerase chain reaction using the comparative threshold cycle (ΔΔCT) method. The nonparametric Mann–Whitney statistical test was applied to determine median differences. We used β-actin as the reference gene in this study. A significant difference and correlation between blood and saliva transcript levels of SIRT1 (r = 0.344) were observed in volunteers. Taken together, these findings indicate that the transcript levels of ERBB2 and SIRT1 measured from saliva have the capacity to be used as diagnostic biomarkers and may minimize the need for performing blood tests.
2020年度
Persistent ID (NDL): info:ndljp/pid/12071388
https://dl.ndl.go.jp/pid/12071388
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2021-04-23
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000276/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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