Identification of MMP-like protein from Streptococcus mitis

Persistent ID (NDL): info:ndljp/pid/12071394

Material type: 博士論文

Author: 麻生, 浩章

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Publication date: 2021-03-05

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Streptococcus mitis is a normal commensal of the human oral cavity and oropharynx. This microorganism is an opportunistic pathogen in immune compromis...

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Material Type: 博士論文
Title: Identification of MMP-like protein from Streptococcus mitis
Author/Editor: 麻生, 浩章
Author Heading: 麻生, 浩章
Publication Date: 2021-03-05
Publication Date (W3CDTF): 2021-03-05
Alternative Title: Streptococcus mitisの保有するMMP様タンパク質の同定
Degree grantor/type: 大阪歯科大学
Date Granted: 2021-03-05
Date Granted (W3CDTF): 2021-03-05
Dissertation Number: 甲第903号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第903号
Text Language Code: eng
Subject Heading: Streptococcus mitis
matrix metalloprotease
collagen
zinc-binding motif
Target Audience: 一般
Note (General): Streptococcus mitis is a normal commensal of the human oral cavity and oropharynx. This microorganism is an opportunistic pathogen in immune compromised hosts and a cause of invasive diseases such as infective endocarditis. We isolated a matrix metalloprotease (MMP)-like protein of S. mitis. The gene for the MMP-like protein was found on the genome sequence database of S. mitis. The gene encodes a protein consisting of 240 amino acid residues with a conserved zinc-binding motif (HEXXHXXGXXH) among the matrix metallopeptidase family. The gene was PCR-amplified from S. mitis ATCC 49456 and cloned for construction of the recombinant protein. The recombinant MMP-like protein with a GST-tag was purified and the enzymatic activity was assessed. The recombinant protein showed approximately half the level of MMP-like activity as compared to human recombinant MMP-8. The MMP-like protein of S. mitis may be involved in the pathogenesis of infection to the dentin with collagen fibers and systemic invasive diseases.
2020年度
Persistent ID (NDL): info:ndljp/pid/12071394
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2021-04-23
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000270/
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