Integration of Epigallocatechin Gallate in Gelatin Sponges Attenuates Matrix Metalloproteinase-Dependent Degradation and Increases Bone Formation

The cover of this title could differ from library to library.

Available in National Diet Library

国立国会図書館デジタルコレクション

Digital data available

Check on the publisher's website

Integration of Epigallocatechin Gallate in Gelatin Sponges Attenuates Matrix Metalloproteinase-Dependent Degradation and Increases Bone Formation

Persistent ID (NDL): info:ndljp/pid/12071493

Material type: 博士論文

Author: 黄, 安祺

Publisher: -

Publication date: 2020-03-06

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 大阪歯科大学,博士（歯学）

View All

Notes on use at the National Diet Library

本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。

Notes on use

Note (General)：: Epigallocatechin gallate(EGCG), which is isolated from green tea, has been shown to have various pharmacological effects. In recent years, we have dev...

Search by Bookstore

Read this material in an accessible format.

View materials in accessible formats for people with print disabilities (1Type)

Search by Bookstore

Read in Disability Resources

Other Services
- テキストデータ check it on 国立国会図書館デジタルコレクション

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
Title: Integration of Epigallocatechin Gallate in Gelatin Sponges Attenuates Matrix Metalloproteinase-Dependent Degradation and Increases Bone Formation
Author/Editor: 黄, 安祺
Author Heading: 黄, 安祺
Publication Date: 2020-03-06
Publication Date (W3CDTF): 2020-03-06
Alternative Title: ゼラチンスポンジへのエピガロカテキンガレートの組み込みはマトリックスプロテアーゼ依存性分解を減弱し骨形成を増強させる
Degree grantor/type: 大阪歯科大学
Date Granted: 2020-03-06
Date Granted (W3CDTF): 2020-03-06
Dissertation Number: 甲第884号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第884号
Text Language Code: eng
Subject Heading: catechin｜bone formation｜anti-inflammatory reaction｜matrix metalloproteinase｜biomaterials
Target Audience: 一般
Note (General): Epigallocatechin gallate(EGCG), which is isolated from green tea, has been shown to have various pharmacological effects. In recent years, we have developed vacuum heated sponge material integrated with epigallocatechin gallate (vhEGCG-GS). Recently, vhEGCG-GS has been proven to have excellent bone regenerative ability. We examined the effects of EGCG on matrix metalloproteinase (MMP)-2 and MMP-9（gelatinases that disintegrate gelatin）expression in gelatin sponges and its association with bone formation. Four kinds of gelatin sponges with or without EGCG were prepared and implanted into bone defects for up to 4 weeks. Histological and immunohistological stainings were then performed. Micro-computed tomography was used to estimate the bone-forming capacity of each group. The results showed that EGCG integration attenuated MMP-2 and -9 expression, increased residual gelatin, and augmented bone formation in critical-sized bone defects of rat calvaria compared with vacuum-heated gelatin sponges without EGCG. In addition, vhEGCG showed superior bone formation compared with other sponges. The results indicated that integration of EGCG in gelatin-based materials modulated the production and activity of MMP-2 and -9 in vivo, thereby enhancing bone-forming capacity.
2019年度
Persistent ID (NDL): info:ndljp/pid/12071493
https://dl.ndl.go.jp/pid/12071493
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2020-04-28
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000247/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp