Integration of Epigallocatechin Gallate in Gelatin Sponges Attenuates Matrix Metalloproteinase-Dependent Degradation and Increases Bone Formation

Persistent ID (NDL): info:ndljp/pid/12071493

Material type: 博士論文

Author: 黄, 安祺

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Publication date: 2020-03-06

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Epigallocatechin gallate(EGCG), which is isolated from green tea, has been shown to have various pharmacological effects. In recent years, we have dev...

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Material Type: 博士論文
Title: Integration of Epigallocatechin Gallate in Gelatin Sponges Attenuates Matrix Metalloproteinase-Dependent Degradation and Increases Bone Formation
Author/Editor: 黄, 安祺
Author Heading: 黄, 安祺
Publication Date: 2020-03-06
Publication Date (W3CDTF): 2020-03-06
Alternative Title: ゼラチンスポンジへのエピガロカテキンガレートの組み込みはマトリックスプロテアーゼ依存性分解を減弱し骨形成を増強させる
Degree grantor/type: 大阪歯科大学
Date Granted: 2020-03-06
Date Granted (W3CDTF): 2020-03-06
Dissertation Number: 甲第884号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第884号
Text Language Code: eng
Subject Heading: catechin｜bone formation｜anti-inflammatory reaction｜matrix metalloproteinase｜biomaterials
Target Audience: 一般
Note (General): Epigallocatechin gallate(EGCG), which is isolated from green tea, has been shown to have various pharmacological effects. In recent years, we have developed vacuum heated sponge material integrated with epigallocatechin gallate (vhEGCG-GS). Recently, vhEGCG-GS has been proven to have excellent bone regenerative ability. We examined the effects of EGCG on matrix metalloproteinase (MMP)-2 and MMP-9（gelatinases that disintegrate gelatin）expression in gelatin sponges and its association with bone formation. Four kinds of gelatin sponges with or without EGCG were prepared and implanted into bone defects for up to 4 weeks. Histological and immunohistological stainings were then performed. Micro-computed tomography was used to estimate the bone-forming capacity of each group. The results showed that EGCG integration attenuated MMP-2 and -9 expression, increased residual gelatin, and augmented bone formation in critical-sized bone defects of rat calvaria compared with vacuum-heated gelatin sponges without EGCG. In addition, vhEGCG showed superior bone formation compared with other sponges. The results indicated that integration of EGCG in gelatin-based materials modulated the production and activity of MMP-2 and -9 in vivo, thereby enhancing bone-forming capacity.
2019年度
Persistent ID (NDL): info:ndljp/pid/12071493
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Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2020-04-28
Format (IMT): application/pdf
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000247/
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