Osteogenic Effects of Glucose Concentration for Human Bone Marrow Stromal Cells after Stimulation with Porphyromonas gingivalis Lipopolysaccharide.

Persistent ID (NDL): info:ndljp/pid/12071500

Material type: 博士論文

Author: 塩見, 慧

Publisher: -

Publication date: 2020-03-06

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Chronic inflammation contributes to the development of DM and DM-associated complications. Hyperglycemia is a hallmark of DM and may contribute to sus...

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Material Type: 博士論文
Title: Osteogenic Effects of Glucose Concentration for Human Bone Marrow Stromal Cells after Stimulation with Porphyromonas gingivalis Lipopolysaccharide.
Author/Editor: 塩見, 慧
Author Heading: 塩見, 慧
Publication Date: 2020-03-06
Publication Date (W3CDTF): 2020-03-06
Alternative Title: ヒト骨髄間葉系細胞の硬組織分化における Porphyromonas gingivalis LPS存在下での高グルコース環境の影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2020-03-06
Date Granted (W3CDTF): 2020-03-06
Dissertation Number: 甲第877号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第877号
Text Language Code: eng
Subject Heading: Bone marrow cells
Hyperglycemia
Porphyromonas gingivalis
Target Audience: 一般
Note (General): Chronic inflammation contributes to the development of DM and DM-associated complications. Hyperglycemia is a hallmark of DM and may contribute to sustained inflammation by increasing the levels of proinflammatory cytokines. However, the mechanisms by which bone-related complications develop in DM after stimulation by the Porphyromonas gingivalis lipopolysaccharide (P. gingivalis LPS) remain unknown. We evaluated the effect of high glucose levels on the biomineralization and inflammation markers in a human osteoblastic cell line, after stimulation with LPS from P. gingivalis. We treated cells with glucose at concentrations 5.5, 8.0, 12 and 24 mM after stimulation with P. gingivalis LPS (1.0 mg/ml) and determined its effects on cell proliferation, alkaline phosphatase (ALP) activity, osteocalcin (OCN) production, calcium deposition, inflammatory cytokines, and osteogenic cytokines. . High glucose concentration decreased hard tissue formation after stimulation by P. gingivalis LPS. Understanding the effect of glucose on osteoblast differentiation and Ca deposition might provide a better understanding of the development and prevention of periodontitis associated with diabetes.
2019年度
Persistent ID (NDL): info:ndljp/pid/12071500
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2020-04-28
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000240/
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