Morphological influence of osteoporosis and bisphosphonates on mandibular glands of rats

Persistent ID (NDL): info:ndljp/pid/12071533

Material type: 博士論文

Author: 西嶋, 一路

Publisher: -

Publication date: 2019-03-27

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 大阪歯科大学,博士（歯学）

View All

Notes on use at the National Diet Library

本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。

Notes on use

Note (General)：: Bisphosphonates (BP) are widely used therapeutic agents for osteoporosis (OP). While many OP patients experience dry mouth, no study has investigated ...

Search by Bookstore

Read this material in an accessible format.

View materials in accessible formats for people with print disabilities (1Type)

Search by Bookstore

Read in Disability Resources

Other Services
- テキストデータ check it on 国立国会図書館デジタルコレクション

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
Title: Morphological influence of osteoporosis and bisphosphonates on mandibular glands of rats
Author/Editor: 西嶋, 一路
Author Heading: 西嶋, 一路
Publication Date: 2019-03-27
Publication Date (W3CDTF): 2019-03-27
Alternative Title: ラット下顎腺における骨粗鬆症及びビスホスホネート製剤の形態学的影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2019-03-27
Date Granted (W3CDTF): 2019-03-27
Dissertation Number: 乙第1617号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 乙第1617号
Text Language Code: eng
Subject Heading: Bisphosphonate｜Microvascular corrosion cast｜Osteoporosis｜Salivary gland
Target Audience: 一般
Note (General): Bisphosphonates (BP) are widely used therapeutic agents for osteoporosis (OP). While many OP patients experience dry mouth, no study has investigated the morphological influence of OP and BP on salivary glands. We investigated the morphological influence of BP on mandibular glands using normal rats and an OP rat model. The study included 36, 8-week-old female Wistar rats. We divided them into OP and SH groups (18 animals each). The rats in the OP group underwent bilateral ovariectomy, and the SH group received a sham operation. Nine rats from each group were injected with BP, and the remaining were injected with normal saline. Both mandibular glands were removed from each animal. The bone density of the femur was measured using micro-computed tomography, cross-sectional areas of acini were measured using optical microscopy, diameters of acini and periacinar capillaries were measured using scanning electron microscopy, and statistical analysis (at 5% significance) was performed. Each measurement for the SH-BP and OP-BP groups were significantly smaller than those of the SH-NS and OP-NS groups. The results suggest that BP administration caused atrophic changes to the mandibular gland tissues and miniaturization of capillaries, thereby reducing the volume of saliva secreted.
2018年度
Persistent ID (NDL): info:ndljp/pid/12071533
https://dl.ndl.go.jp/pid/12071533
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2019-05-17
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000207/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp