Expression of E-, P-, and N-cadherin and α-, β-, and γ-catenin with respect to invasion in ameloblastoma

Persistent ID (NDL): info:ndljp/pid/12071542

Material type: 博士論文

Author: 成瀬, かおり

Publisher: -

Publication date: 2019-03-08

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Ameloblastoma consists of an odontogenic epithelium and is a benign tumor without odontogenic mesenchyme. It occurs primarily in the jawbone and exhib...

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Material Type: 博士論文
Title: Expression of E-, P-, and N-cadherin and α-, β-, and γ-catenin with respect to invasion in ameloblastoma
Author/Editor: 成瀬, かおり
Author Heading: 成瀬, かおり
Publication Date: 2019-03-08
Publication Date (W3CDTF): 2019-03-08
Alternative Title: エナメル上皮腫におけるE-, P-, N-cadherin, α-, β-, γ-cateninの発現の検討
Degree grantor/type: 大阪歯科大学
Date Granted: 2019-03-08
Date Granted (W3CDTF): 2019-03-08
Dissertation Number: 甲第845号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第845号
Text Language Code: eng
Subject Heading: cadherin
catenin
ameloblastoma
immunohistochemistry
Target Audience: 一般
Note (General): Ameloblastoma consists of an odontogenic epithelium and is a benign tumor without odontogenic mesenchyme. It occurs primarily in the jawbone and exhibits locally invasive growth. To clarify the factors involved in the invasion of ameloblastoma, the expression profiles of E-, P- and N-cadherin and α-, β- and γ-catenin were examined in 39 cases of ameloblastoma by immunohistochemistry. Cadherin and catenin were expressed on tumor cell membranes. Of the examined cases, 12 exhibited reduced E-cadherin expression, 12 exhibited strong P-cadherin expression, and 7 exhibited weak expression of N-cadherin. Additionally, 20 cases exhibited reduced α-catenin expression, 8 exhibited reduced β-catenin expression, and 33 cases exhibited reduced γ-catenin expression. Reduced expression of E-cadherin was associated with decreased cell adhesion, and strong expression of P-cadherin was associated with cell proliferation. Expression of N-cadherin was related to tumor invasion and suggested involvement in epithelial mesenchymal transition. In addition, reduced α-catenin in the expression region of E-cadherin suggested an abnormal function of E-cadherin. Together, these results suggest that cadherin and catenin play important roles in the development and local invasiveness of ameloblastoma.
2018年度
Persistent ID (NDL): info:ndljp/pid/12071542
https://dl.ndl.go.jp/pid/12071542
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2019-05-17
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000198/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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