Interleukin-6, Matrix Metallopeptidase-9 Expression in Three-dimensional Tumor Microenvironment using Oral Cancer Cells

Persistent ID (NDL): info:ndljp/pid/12071543

Material type: 博士論文

Author: 中西, 環

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Publication date: 2019-03-08

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Cancer tissues strongly depend on the cancer microenvironment specifically observed around cancer, where immune cell infiltration and angiogenesis, as...

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Material Type: 博士論文
Title: Interleukin-6, Matrix Metallopeptidase-9 Expression in Three-dimensional Tumor Microenvironment using Oral Cancer Cells
Author/Editor: 中西, 環
Author Heading: 中西, 環
Publication Date: 2019-03-08
Publication Date (W3CDTF): 2019-03-08
Alternative Title: 口腔癌由来細胞を用いた三次元腫瘍微小環境のin vitroモデルにおけるIL-6, MMP-9の発現
Degree grantor/type: 大阪歯科大学
Date Granted: 2019-03-08
Date Granted (W3CDTF): 2019-03-08
Dissertation Number: 甲第844号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第844号
Text Language Code: eng
Subject Heading: IL-6
MMP-9
ECM
RT-PCR
HSC-4
Target Audience: 一般
Note (General): Cancer tissues strongly depend on the cancer microenvironment specifically observed around cancer, where immune cell infiltration and angiogenesis, as well as fibroblast proliferation, are induced in comparison with normal tissues. Various three-dimensional culturing methods for solid cancer cells have already been reported as in vitro experimental methods to reflect the characteristics of cancers. The spheroid cultures, constructed with cancer cells, should more accurately reflect the biological characteristics of cancers than two-dimensional cul-tures. However, solid cancers applicable to spheroid culturing are still limited. Previously, we compared the results of inflammatory cytokine Interleukin-6 (IL-6) between two-dimensional culture and spheroid culture with HSC-4 cells derived from human oral squamous cell car-cinoma collected from the tongue. In the present study, besides IL-6, the expression of Matrix Metalloproteinase-9 (MMP-9), which plays an important role in the infiltration and metastasis of cancer cells surrounded by ECM, was examined by real-time RT-PCR, and the sizes of spheroids were observed over time.
2018年度
Persistent ID (NDL): info:ndljp/pid/12071543
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2019-05-17
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000197/
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