Lung Cancer Risk in Passive Smokers using Salivary Exosome-Derived MicroRNAs

Persistent ID (NDL): info:ndljp/pid/12071545

Material type: 博士論文

Author: 井戸垣, 潤

Publisher: -

Publication date: 2019-03-08

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: The objective of this study was to investigate the lung cancer risk in passive smokers using salivary exosome-derived microRNAs (mirs). Individuals we...

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Material Type: 博士論文
Title: Lung Cancer Risk in Passive Smokers using Salivary Exosome-Derived MicroRNAs
Author/Editor: 井戸垣, 潤
Author Heading: 井戸垣, 潤
Publication Date: 2019-03-08
Publication Date (W3CDTF): 2019-03-08
Alternative Title: 唾液中エクソソーム由来マイクロRNAを用いた受動喫煙者の肺がんリスク調査
Degree grantor/type: 大阪歯科大学
Date Granted: 2019-03-08
Date Granted (W3CDTF): 2019-03-08
Dissertation Number: 甲第842号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第842号
Text Language Code: eng
Subject Heading: carbon monoxide｜ microRNA｜ passive smoke｜ lung cancer risk｜ salivary exosomes
Target Audience: 一般
Note (General): The objective of this study was to investigate the lung cancer risk in passive smokers using salivary exosome-derived microRNAs (mirs). Individuals were confirmed to be passive smokers by inter-viewing them using the Kano Test for Social Nicotine Dependence (KTSND) and measuring exhaled breath carbon monoxide (eBCO) level. Unstimulated saliva samples were collected from 25 students, and exosomes were isolated from salivary supernatants. Total RNA was isolated from the isolated exosome and washed and spun repeatedly using a filter cartridge to obtain the total RNA. Digital PCR was performed using mir-22, mir-150, and mir-155, which are related to lung cancer; mir-191 was used as the endogenous control. Salivary exosome samples considered posi-tive by the carbon monoxide breath analysis monitor exhibited expression of mir-22, mir-150, and mir-155, that reportedly have increased expression in lung cancer. These findings indicate the possibility of investigating lung cancer risk in passive smokers using salivary exosome-derived mirs.
2018年度
Persistent ID (NDL): info:ndljp/pid/12071545
https://dl.ndl.go.jp/pid/12071545
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2019-05-17
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000195/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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