Alternative Title純チタン金属表面上のナノ構造がラット歯根膜細胞の挙動に与える影響
Note (General)When natural teeth are lost, endosseous implants anchored via intimate bone-to-implant contacts are considered an appropriate replacement. The interactions between implants and host tissues depend on several factors. In particular, a growing body of evidence has demonstrated that the surface texture of an implant influences the response of the surrounding cells. Recent studies have shown that treating titanium with aqueous NaOH produces a nanostructured surface texture termed a titanium nanosheet (TNS). Furthermore, it was recently reported that a TNS surface promoted the osteogenic differentiation of rat bone marrow cells. We investigated whether a TNS surface may improve wound healing around endosseous implants. To test this, we assessed the effects of a TNS surface on the adhesion and differentiation of rat periodontal ligament (RPL) cells in vitro. The results demonstrated that RPL cells cultured on a TNS surface showed more adhesion and higher levels of osteogenic differentiation markers (Runx2 expression, alkaline phosphatase activity, calcium deposition, and osteocalcin secretion) than cells cultured on unmodified titanium. These findings indicate that RPL cells have the potential for increased bone formation on a TNS surface. Thus, TNS surface modification may warrant consideration for use in endosseous dental implants.
2017年度
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2022-02-06T04:33:19+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション