Functional recovery by application of human dedifferentiated fat cells on cerebral infarction mice model

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Functional recovery by application of human dedifferentiated fat cells on cerebral infarction mice model

Persistent ID (NDL): info:ndljp/pid/12071573

Material type: 博士論文

Author: 覺道, 知樹

Publisher: -

Publication date: 2018-03-09

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Elderly people whose daily activities have declined due to a cerebrovascular disorder may suffer from dysphagia and may find oral hygiene difficult. T...

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Material Type: 博士論文
Title: Functional recovery by application of human dedifferentiated fat cells on cerebral infarction mice model
Author/Editor: 覺道, 知樹
Author Heading: 覺道, 知樹
Publication Date: 2018-03-09
Publication Date (W3CDTF): 2018-03-09
Alternative Title: マウス脳梗塞モデルにおけるヒト脱分化脂肪細胞による機能回復
Degree grantor/type: 大阪歯科大学
Date Granted: 2018-03-09
Date Granted (W3CDTF): 2018-03-09
Dissertation Number: 甲第822号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第822号
Text Language Code: eng
Subject Heading: Adipose stem cell
Cerebral infarction
Cerebrovascular disorder
Nestin
Neural differentiation
Transplantation
Target Audience: 一般
Note (General): Elderly people whose daily activities have declined due to a cerebrovascular disorder may suffer from dysphagia and may find oral hygiene difficult. Therefore, it is important to establish an effective therapy for the underlying cerebrovascular disorder. Dedifferentiated fat cells (DFAT) were obtained from mature adipocytes isolated from human buccal adipose pads in a ceiling culture. DFAT expressed the neural markers Nestin and SOX2. Flow cytometric analysis revealed that the cells had properties similar to mesenchymal stem cells. Although the transplantation of DFAT did not change the infarction area and volume ratios in a murine cerebral infarction model, functional recovery was observed in behavioral tests. Furthermore, DFAT administered to mice were later detected in cerebral infarctions. It therefore appears that transplanted DFAT affect the brain after infarction and contribute to the promotion of functional recovery. This finding may provide new cell replacement therapy options for treating disorders of the central nervous system.
2017年度
Persistent ID (NDL): info:ndljp/pid/12071573
https://dl.ndl.go.jp/pid/12071573
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2018-05-17
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000165/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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