Bactericidal effect of performic acid on salivary bacteria

Persistent ID (NDL): info:ndljp/pid/12071574

Material type: 博士論文

Author: 森岡, 裕貴

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Publication date: 2018-03-09

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Although heat-sensitive semi-critical medical devices (e.g., transnasal endoscopes) should undergo high-level disinfection between patients, these dev...

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Material Type: 博士論文
Title: Bactericidal effect of performic acid on salivary bacteria
Author/Editor: 森岡, 裕貴
Author Heading: 森岡, 裕貴
Publication Date: 2018-03-09
Publication Date (W3CDTF): 2018-03-09
Alternative Title: 過ギ酸による唾液細菌に対する殺菌効果
Degree grantor/type: 大阪歯科大学
Date Granted: 2018-03-09
Date Granted (W3CDTF): 2018-03-09
Dissertation Number: 甲第821号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第821号
Text Language Code: eng
Subject Heading: Performic acid｜Bactericidal activity｜Salivary bacteria
Target Audience: 一般
Note (General): Although heat-sensitive semi-critical medical devices (e.g., transnasal endoscopes) should undergo high-level disinfection between patients, these devices are often harmful to humans and the environment due to their residual toxicity caused by disinfectants. We analyzed the bactericidal activity against salivary bacteria of performic acid (PFA) which has strong antibacterial activity and has shown a consistent absence of genotoxic and mutagenic effects on human cells. Collected saliva samples were mixed with various concentrations of PFA. After incubation, bactericidal activity was assessed with colony-forming assays and quantification of ATP produced by metabolically active cells. Even for a 1-minute exposure, PFA showed a strong bactericidal effect against salivary bacteria, in which more than 99.9% and 67.1% of bacterial colonies were suppressed at 8×10-4% (w/v) and 8×10-6% (w/v) PFA, respectively. This effect was enhanced by prolonged incubation. Bacterial viability assay based on ATP measurement also showed concentration-dependent bactericidal effects of PFA. PFA showed comparatively strong antibacterial activity against salivary bacteria, even with short duration exposure.
2017年度
Persistent ID (NDL): info:ndljp/pid/12071574
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2018-05-17
Format (IMT): application/pdf
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Periodical Title (URI): http://id.nii.ac.jp/1392/00000164/
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