Surface modification of porous alpha-tricalcium phosphate granules with heparin enhanced their early osteogenic capability in a rat calvarial defect model

Persistent ID (NDL): info:ndljp/pid/12071577

Material type: 博士論文

Author: 武田, 吉裕

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Publication date: 2018-03-09

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Heparin binds to and modulates various growth factors, potentially augmenting the bone-forming capability of biomaterials. Here, α-tricalcium phosphat...

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Material Type: 博士論文
Title: Surface modification of porous alpha-tricalcium phosphate granules with heparin enhanced their early osteogenic capability in a rat calvarial defect model
Author/Editor: 武田, 吉裕
Author Heading: 武田, 吉裕
Publication Date: 2018-03-09
Publication Date (W3CDTF): 2018-03-09
Alternative Title: ヘパリンによる表面修飾はα型リン酸三カルシウム多孔質顆粒の初期骨形成能を増強する
Degree grantor/type: 大阪歯科大学
Date Granted: 2018-03-09
Date Granted (W3CDTF): 2018-03-09
Dissertation Number: 甲第818号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第818号
Text Language Code: eng
Subject Heading: heparin
calcium phosphate
α-tricalcium phosphate
critical size defects
surface modification
Target Audience: 一般
Note (General): Heparin binds to and modulates various growth factors, potentially augmenting the bone-forming capability of biomaterials. Here, α-tricalcium phosphate (α-TCP) granules were modified with peptide containing the marine mussel-derived adhesive sequence, which reacts with α-TCP surface, and cationic sequence, which binds to heparin (α-Ph).α-Ph retained the α-TCP phase and intergranule spaces after the surface modification. The existence of heparin on α-Ph granules was confirmed using x-ray photoelectron spectroscopy. Granules of α-TCP and α-Ph were implanted into critical-size defects in rat calvaria for 4 weeks. Micro-computed tomography, histological evaluation, and Alcian blue staining revealed that α-Ph induced superior bone formation compared with α-TCP. Newly formed bone on α-Ph was preferentially in contact with the Alcian blue-stained surfaces of granules. These results suggested that heparinization enhanced the early osteogenic capacity of α-TCP, possibly by modulating the secretion of Alcian blue-stained extracellular matrixes.
2017年度
Persistent ID (NDL): info:ndljp/pid/12071577
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2018-05-17
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000161/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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