Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland

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Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland

Persistent ID (NDL): info:ndljp/pid/12071591

Material type: 博士論文

Author: 松下, 巧

Publisher: -

Publication date: 2017-03-10

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Development of the salivary gland is characterized by extensive branching morphogenesis and lumen formation as well as differentiation into acinar and...

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Material Type: 博士論文
Title: Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland
Author/Editor: 松下, 巧
Author Heading: 松下, 巧
Publication Date: 2017-03-10
Publication Date (W3CDTF): 2017-03-10
Alternative Title: マウス顎下腺発生過程における転写因子 Grhl2 とその標的遺伝子の発現
Degree grantor/type: 大阪歯科大学
Date Granted: 2017-03-10
Date Granted (W3CDTF): 2017-03-10
Dissertation Number: 甲第807号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第807号
Text Language Code: eng
Subject Heading: Grhl2
SPINT1
Matriptase
Salivary gland
Development
Target Audience: 一般
Note (General): Development of the salivary gland is characterized by extensive branching morphogenesis and lumen formation as well as differentiation into acinar and ductal cells. Although various molecules have been implicated in salivary gland development, transcription factors regulating the expression of those molecules and salivary gland development are largely unknown. The GRHL2 transcription factor and its target gene product SPINT1 as well as the SPINT1-regualted protease matriptase play crucial roles in epithelial development in several organs. Here we examined the expression of these epithelial regulators in developing mouse SMG. Of the three Grhl gene members, Grhl2 was the most abundant in embryonic SMG. The expression levels of GRHL2, SPINT1 and matriptase were increased during development of the gland. All of these molecules were expressed exclusively in the epithelial tissue. The present data may suggest the involvement of these molecules in SMG development and give a clue to developing a regenerative therapy of damaged salivary glands.
2016年度
Persistent ID (NDL): info:ndljp/pid/12071591
https://dl.ndl.go.jp/pid/12071591
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2017-04-19
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000147/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp