Differential expression of the epithelial mesenchymal transition factors Snail, Slug, Twist, TGF-β, and E-cadherin in ameloblastoma

Persistent ID (NDL): info:ndljp/pid/12071596

Material type: 博士論文

Author: 栗岡, 香美

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Publication date: 2017-03-10

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Epithelial mesenchymal transition (EMT), the transition of epithelial cells into motile mesenchymal cells,plays an important role in embryogenesis, ca...

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Material Type: 博士論文
Title: Differential expression of the epithelial mesenchymal transition factors Snail, Slug, Twist, TGF-β, and E-cadherin in ameloblastoma
Author/Editor: 栗岡, 香美
Author Heading: 栗岡, 香美
Publication Date: 2017-03-10
Publication Date (W3CDTF): 2017-03-10
Alternative Title: エナメル上皮腫における上皮間葉転写因子 Snail, Slug, Twist, TGF-β, E-cadherin の発現
Degree grantor/type: 大阪歯科大学
Date Granted: 2017-03-10
Date Granted (W3CDTF): 2017-03-10
Dissertation Number: 甲第802号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第802号
Text Language Code: eng
Subject Heading: Epithelial mesenchymal transition (EMT)
Ameloblastoma
Immunohistochemistry
Double immunostaining
Snail
Slug
E-cadherin
Target Audience: 一般
Note (General): Epithelial mesenchymal transition (EMT), the transition of epithelial cells into motile mesenchymal cells,plays an important role in embryogenesis, cancer invasion,and metastasis. Ameloblastomas are common epithelialodontogenic tumors, occurring exclusively in the mandible with locally invasive growth. Thirty-seven ameloblastoma cases were evaluated for the involvement of EMT by immunohistochemical staining and western blotting using antibodies against Slug, Snail, Twist, TGF-b, and E-cadherin. Double immunostaining was also performed. Slug and TGF-b were expressed in the nuclei of peripheral and stellate reticulum cells of ameloblastoma nests. Twenty cases of Snail, 36 of Slug, 8 of Twist, and 19 of TGF-b showed strong expression in tumor cells in follicular and plexiform patterns. Expression of Slug and TGF-b increased in regions where the expression of E-cadherin was reduced. EMT was found to be associated with thelocal invasive growth of ameloblastoma. These data suggest that reduced expression of E-cadherin and over-expression of Slug, Snail, and TGF-b induce EMT. Given that ameloblastomas are characterized by local invasiveness, EMT might be related to their development. Thus, strong expression of Slug and TGF-b and reduced expression of E-cadherin might be related to the local invasiveness of ameloblastoma.
2016年度
Persistent ID (NDL): info:ndljp/pid/12071596
https://dl.ndl.go.jp/pid/12071596
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2017-04-19
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000142/
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