HGF/c-Met induces cell migration of oral squamous cell carcinoma via lamellipodin

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HGF/c-Met induces cell migration of oral squamous cell carcinoma via lamellipodin

Persistent ID (NDL): info:ndljp/pid/12071602

Material type: 博士論文

Author: 安井, 大樹

Publisher: -

Publication date: 2017-03-10

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Cell migration potency is often regulated by extracellular stimuli. We previously reported that the migration potency of the oral squamous cell carcin...

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Material Type: 博士論文
Title: HGF/c-Met induces cell migration of oral squamous cell carcinoma via lamellipodin
Author/Editor: 安井, 大樹
Author Heading: 安井, 大樹
Publication Date: 2017-03-10
Publication Date (W3CDTF): 2017-03-10
Alternative Title: HGF/c-Metはlamellipodinを介して口腔扁平上皮癌細胞の細胞遊走を誘導する
Degree grantor/type: 大阪歯科大学
Date Granted: 2017-03-10
Date Granted (W3CDTF): 2017-03-10
Dissertation Number: 甲第796号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第796号
Text Language Code: eng
Subject Heading: c-Met｜HGF｜AG1478｜SU11274｜Lamellipodin｜Cell migration
Target Audience: 一般
Note (General): Cell migration potency is often regulated by extracellular stimuli. We previously reported that the migration potency of the oral squamous cell carcinoma (OSCC) cell lines SAS and HSC3 have high epidermal growth factor receptor (EGFR) inhibitor sensitivity, while the migration of HSC4 is not affected. Hepatocyte growth factor (HGF)/c-Met is known as one of the signaling pathways for cell migration in some cancer cells. In this study, we demonstrated the importance of the c-Met signaling pathway for filopodia and lamellipodia formation in cell migration using HSC4. The cell migration of HSC4 used the HGF/c-Met pathway. Additionally, the EGF/EGFR pathway is not related to lamellipodia formation. The HGF/c-Met pathway is important for the formation of filopodia and lamellipodia in HSC4. Furthermore, signaling from c-Met increases the amount of lamellipodin protein, which is necessary for formation of lamellipodia. Our results suggested that signaling from the HGF/c-Met pathway increases the quantity of lamellipodin protein, and induces cell migratory capacity by inducing lamellipodia forming potency in HSC4.
2016年度
Persistent ID (NDL): info:ndljp/pid/12071602
https://dl.ndl.go.jp/pid/12071602
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2017-04-19
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000136/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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