The Effect of Interferon-γ and Zoledronate Treatment on Alpha-Tricalcium Phosphate/Collagen Sponge-Mediated Bone-Tissue Engineering

Persistent ID (NDL): info:ndljp/pid/12071625

Material type: 博士論文

Author: 李, 佩祺

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Publication date: 2016-03-11

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Inflammatory responses are frequently associated with the expression of inflammatory cytokines and severe osteoclastogenesis, which significantly affe...

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Material Type: 博士論文
Title: The Effect of Interferon-γ and Zoledronate Treatment on Alpha-Tricalcium Phosphate/Collagen Sponge-Mediated Bone-Tissue Engineering
Author/Editor: 李, 佩祺
Author Heading: 李, 佩祺
Publication Date: 2016-03-11
Publication Date (W3CDTF): 2016-03-11
Alternative Title: αリン酸三カルシウムコラーゲンスポンジを用いた骨再生に対するインターフェロンγとゾレドロネートの効果
Degree grantor/type: 大阪歯科大学
Date Granted: 2016-03-11
Date Granted (W3CDTF): 2016-03-11
Dissertation Number: 甲第785号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第785号
Text Language Code: eng
Subject Heading: bone tissue engineering
α-TCP/CS
inflammatory response
RANKL
TNF-α
osteoclastogenesis
interferon-γ
zoledronate
Target Audience: 一般
Note (General): Inflammatory responses are frequently associated with the expression of inflammatory cytokines and severe osteoclastogenesis, which significantly affect the efficacy of biomaterials. Recent findings have suggested that interferon (IFN)-γ and zoledronate (Zol) are effective inhibitors of osteoclastogenesis. However, little is known regarding the utility of IFN-γ and Zol in bone tissue engineering. In this study, we generated rat models by generating critically sized defects in calvarias implanted with an alpha-tricalcium phosphate/collagen sponge (α-TCP/CS). At four weeks post-implantation, the rats were divided into IFN-γ, Zol, and control (no treatment) groups. Compared with the control group, the IFN-γ and Zol groups showed remarkable attenuation of severe osteoclastogenesis, leading to a significant enhancement in bone mass. Histomorphometric data and mRNA expression patterns in IFN-γ and Zol-injected rats reflected high bone-turnover with increased bone formation, a reduction in osteoclast numbers, and tumor necrosis factor-α expression. Our results demonstrated that the administration of IFN-γ and Zol enhanced bone regeneration of α-TCP/CS implants by enhancing bone formation, while hampering excess bone resorption.
2015
Persistent ID (NDL): info:ndljp/pid/12071625
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2016-07-19
Format (IMT): application/pdf
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Periodical Title (URI): http://id.nii.ac.jp/1392/00000106/
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