Comparison of EEG analysis systems during lidocaine-induced seizure activity and administration of valproic acid in rabbits

Persistent ID (NDL): info:ndljp/pid/12071630

Material type: 博士論文

Author: 中田, 雅代

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Publication date: 2016-03-11

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Based on algorithm differences between aperiodic and power spectrum analysis of the electroencephalogram (EEG), we hypothesized that the effects on th...

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Material Type: 博士論文
Title: Comparison of EEG analysis systems during lidocaine-induced seizure activity and administration of valproic acid in rabbits
Author/Editor: 中田, 雅代
Author Heading: 中田, 雅代
Publication Date: 2016-03-11
Publication Date (W3CDTF): 2016-03-11
Alternative Title: リドカイン誘発痙攣とバルプロ酸投与における脳波解析システムの比較
Degree grantor/type: 大阪歯科大学
Date Granted: 2016-03-11
Date Granted (W3CDTF): 2016-03-11
Dissertation Number: 甲第780号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第780号
Text Language Code: eng
Subject Heading: Aperiodic analysis
Power spectrum analysis
Lidocaine
Valproic acid
Target Audience: 一般
Note (General): Based on algorithm differences between aperiodic and power spectrum analysis of the electroencephalogram (EEG), we hypothesized that the effects on the EEG of an antiepileptic drug would be equally well detected with either lidocaine-induced seizure by aperiodic analysis or by power spectrum analysis. However, the former is superior. EEG activity was recorded in anesthetized rabbits prior to intravenous infusion of valproic acid and lidocaine and after the onset of EEG activity. Values for delta, theta, alpha, beta, and total activity, as well as edge frequency were compared within each group, and were expressed as percent change from baseline for comparison between aperiodic and power spectrum analysis. With valproic acid, EEG changes were modest and the two methods of EEG analysis were significantly different from one another for only two of the 12 comparisons. With lidocaine, the lidocaine-induced seizure activity was associated with widespread EEG changes which were better detected by aperiodic analysis than by power spectrum analysis. Comparison between the two methods of analysis indicated significant differences for theta, alpha, and beta activity and edge frequency. These results indicate that both methods of analysis may be suitable to detect modest drug-induced EEG changes, whereas aperiodic analysis is superior for detection of widespread seizure activity.
2015
Persistent ID (NDL): info:ndljp/pid/12071630
https://dl.ndl.go.jp/pid/12071630
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2016-07-19
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000101/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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