The Effect of Phenytoin on the Matrix Metalloprotease-3 Production in HGFs

Persistent ID (NDL): info:ndljp/pid/12071633

Material type: 博士論文

Author: 香川, 真貴子

Publisher: -

Publication date: 2016-03-11

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Special care must be taken in the orthodontic treatment of patients who are medicating with phenytoin, which has a side effect of gingival overgrowth....

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Material Type: 博士論文
Title: The Effect of Phenytoin on the Matrix Metalloprotease-3 Production in HGFs
Author/Editor: 香川, 真貴子
Author Heading: 香川, 真貴子
Publication Date: 2016-03-11
Publication Date (W3CDTF): 2016-03-11
Alternative Title: ヒト歯肉線維芽細胞におけるMatrix metalloproteinase-3産生に及ぼすフェニトインの影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2016-03-11
Date Granted (W3CDTF): 2016-03-11
Dissertation Number: 甲第777号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第777号
Text Language Code: eng
Subject Heading: Phenytoin
Matrix metalloproteinase-3
Human gingival fibroblast
Target Audience: 一般
Note (General): Special care must be taken in the orthodontic treatment of patients who are medicating with phenytoin, which has a side effect of gingival overgrowth. However, the mechanism of this side effect is not yet known in detail.Gingival overgrowth is termed hatred by inflammation, and it has been reported that when inflammation occurs during phenytoin treatment the movement of the teeth is delayed. Therefore, in the present study, it was decided to investigate the mechanisms of phenytoin by focusing on matrix metalloproteinases (MMPs) that are expressed as a result of inflammation.In this study, we demonstrated that the production of MMP-3 in TNF-α-stimulated Human gingival fibroblasts (HGFs) is suppressed by phenytoin. In addition, phenytoin suppressed the phosphorylation of NFκB in TNF-α stimulated HGFs. These results suggested that phenytoin stimulation regulated the production of MMP-3 in inflammatory HGFs, and that phenythoin stimulation involves NFκB signaling.
2015
Persistent ID (NDL): info:ndljp/pid/12071633
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2016-07-19
Format (IMT): application/pdf
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Periodical Title (URI): http://id.nii.ac.jp/1392/00000098/
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