Gene expression profile of side population cells in human oral cancer cell line SCC-4

Persistent ID (NDL): info:ndljp/pid/12071640

Material type: 博士論文

Author: 西五辻, 理江

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Publication date: 2016-03-11

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: To define the properties of side population (SP) cells of the oral squamous cell　carcinoma cell line SCC-4, we compared their gene expression profile ...

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Material Type: 博士論文
Title: Gene expression profile of side population cells in human oral cancer cell line SCC-4
Author/Editor: 西五辻, 理江
Author Heading: 西五辻, 理江
Publication Date: 2016-03-11
Publication Date (W3CDTF): 2016-03-11
Alternative Title: ヒト口腔がん細胞株SCC-4におけるside population細胞の性状解析
Degree grantor/type: 大阪歯科大学
Date Granted: 2016-03-11
Date Granted (W3CDTF): 2016-03-11
Dissertation Number: 甲第769号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第769号
Text Language Code: eng
Subject Heading: Gene expression
Oral cancer
Side population
Anti-cancer drug
Drug resistance
Target Audience: 一般
Note (General): To define the properties of side population (SP) cells of the oral squamous cell　carcinoma cell line SCC-4, we compared their gene expression profile with that of main population (MP) cells. SP cells accounted for approximately 1.5% of the cell population. The gene expression profile in SP cells versus MP cells revealed that 15.8% of genes were up-regulated by more than 10%, and 16.6% were down-regulated by more than 10%. Gene Ontology and KEGG pathway enrichment analyses were carried out on the DAVID online tool for 26,879 distinct probes (p < 0.05). The terms involved in immune/inflammatory responses, cell migration and angiogenesis were detected as up-regulated genes. The terms related to DNA replication, DNA metabolic process, mismatch repair (MMR) and base excretion repair were detected as down-regulated genes. Moreover, mRNAs encoding the ABC transporters ABCG2/BCRP1 and ABCC2/MRP2, which mediate the excretion of anti-cancer drugs such as cisplatin and gefitinib, respectively, were expressed at higher levels. In contrast, the level of mRNA encoding the SLC transporter SLC29A1/ENT1, which mediates the uptake of anti-cancer drugs such as fluorouracil, was decreased. These results indicate that SCC-4 SP cells might be potentially resistant to anti-cancer drugs.
2015
Persistent ID (NDL): info:ndljp/pid/12071640
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2016-07-19
Format (IMT): application/pdf
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000091/
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