Expression patterns of CD66a and CD117 in the mouse submandibular gland

Persistent ID (NDL): info:ndljp/pid/12071643

Material type: 博士論文

Author: 竹山, 旭

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Publication date: 2015-03-06

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: The epithelial tissue of the salivary gland consists of the acinar and ductal parts, the latter of which is further divided into the intercalated, str...

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Material Type: 博士論文
Title: Expression patterns of CD66a and CD117 in the mouse submandibular gland
Author/Editor: 竹山, 旭
Author Heading: 竹山, 旭
Publication Date: 2015-03-06
Publication Date (W3CDTF): 2015-03-06
Alternative Title: CD117 と CD66a による唾液腺上皮細胞の分類
Degree grantor/type: 大阪歯科大学
Date Granted: 2015-03-06
Date Granted (W3CDTF): 2015-03-06
Dissertation Number: 甲第761号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第761号
Text Language Code: eng
Subject Heading: Animals
Carcinoembryonic Antigen
Female
Gene Expression Regulation
Mice
Proto-Oncogene Proteins c-kit
Salivary Ducts
Submandibular Gland
Target Audience: 一般
Note (General): The epithelial tissue of the salivary gland consists of the acinar and ductal parts, the latter of which is further divided into the intercalated, striated and excretory duct segments and is the residential site for salivary stem/progenitor cells. In the present study, the expression patterns of two cell surface molecules, CD66a and CD117, were investigated in the adult mouse submandibular glands (SMG) by immunofluorescence microscopy. Combinations of the two molecules differentially marked several types of SMG epithelial cells, including acinar cells (CD66a-intense, CD117-negative), intercalated duct cells (CD66a-intense, CD117-positive), a subset of the striated and excretory duct cells (CD66a-weak, CD117-positive). Most of the CD117-positive ductal cells were negative for cytokeratin 5 and overlapped with the NKCC1-expressing cells. The CD117- and keratin 5-positive cells resided only in the excretory duct were suggested to correspond to the recently identified salivary stem cells. CD66a and CD117 may be useful markers to isolate several cell types consisting of SMG epithelium and to analyze their molecular and cellular nature. Our data also suggest that CD117-expressing epithelial cells of the gland include at least two distinct populations of the stem/progenitor cells.
2014年度
Persistent ID (NDL): info:ndljp/pid/12071643
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2016-07-15
Format (IMT): application/pdf
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000087/
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