Activation of microglia in the nucleus of the solitary tract by inferior alveolar nerve injury

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Activation of microglia in the nucleus of the solitary tract by inferior alveolar nerve injury

Persistent ID (NDL): info:ndljp/pid/12071652

Material type: 博士論文

Author: 柿原, 理奈

Publisher: 大阪歯科学会

Publication date: 2015-03-06

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Deafferentation of somatosensory trigeminal nerves innervating dental pulp and periodontal tissue results in a higher taste threshold persisting for a...

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Material Type: 博士論文
Title: Activation of microglia in the nucleus of the solitary tract by inferior alveolar nerve injury
Author/Editor: 柿原, 理奈
Author Heading: 柿原, 理奈
Publication, Distribution, etc.: 大阪歯科学会
Publication Date: 2015-03-06
Publication Date (W3CDTF): 2015-03-06
Alternative Title: 下⻭槽神経損傷による孤束核内のマイクログリアの活性化
Degree grantor/type: 大阪歯科大学
Date Granted: 2015-03-06
Date Granted (W3CDTF): 2015-03-06
Dissertation Number: 甲第746号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第746号
Text Language Code: eng
Subject Heading: Microglia
Nucleus of solitary tract (NST)
Inferior alveolar nerve (IAN)
Target Audience: 一般
Note (General): Deafferentation of somatosensory trigeminal nerves innervating dental pulp and periodontal tissue results in a higher taste threshold persisting for a long time in humans. The dental and taste nerves converge on neurons in the rostral nucleus of the solitary tract (rNST), suggesting somatosensory and taste input interact in processing taste information in the rNST. Peripheral injury to the inferior alveolar nerve (IAN), one of the dental nerves, leads to glial responses predominantly in the trigeminal spinal subnucleus caudalis and spinal dorsal horn, and abnormal pain sensation via a mechanism involving the active microglia. We examined the microglial response in another primary IAN terminal, the NST, after transection of the IAN (IANx) to reveal a mechanism of abnormal taste sensation after peripheral injury to the dental nerves. By 7 days post-IANx, a cluster of microglial cells appeared in and around the rostral-most portion of the NST, indicating that nerve damage to the IAN results in a microglial response in the rNST, which may participate in initiating abnormal taste sensations following IAN injury.
2014年度
Persistent ID (NDL): info:ndljp/pid/12071652
https://dl.ndl.go.jp/pid/12071652
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2016-06-20
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000025/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp