Effect of hyaluronan on osteoclast differentiation in mouse bone marrow-derived cells cocultured with primary osteoblasts

Persistent ID (NDL): info:ndljp/pid/12071662

Material type: 博士論文

Author: 廣⽥, 秀逸

Publisher: 大阪歯科学会

Publication date: 2015-03-06

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Hyaluronan (HA) is widely used as a disease-modifying drug to reduce pain in patients with osteoarthritis. We investigated whether the commercially av...

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Material Type: 博士論文
Title: Effect of hyaluronan on osteoclast differentiation in mouse bone marrow-derived cells cocultured with primary osteoblasts
Author/Editor: 廣⽥, 秀逸
Author Heading: 廣⽥, 秀逸
Publication, Distribution, etc.: 大阪歯科学会
Publication Date: 2015-03-06
Publication Date (W3CDTF): 2015-03-06
Alternative Title: マウス⾻髄由来細胞と⾻芽細胞の共培養系でのヒアルロン酸の破⾻細胞分化に及ぼす影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2015-03-06
Date Granted (W3CDTF): 2015-03-06
Dissertation Number: 甲第751号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第751号
Text Language Code: eng
Subject Heading: Hyaluronan
Coculture
Osteoclast differentiation
Target Audience: 一般
Note (General): Hyaluronan (HA) is widely used as a disease-modifying drug to reduce pain in patients with osteoarthritis. We investigated whether the commercially available HA product Artz^[○!R] contributes to bone regeneration. To assess whether exogenous HA influences bone resorption and formation, we examined osteoclast differentiation in mouse bone marrow-derived cells co- cultured with primary mouse calvarial osteoblasts, and also analyzed the proliferation and adhesion of these cells. Coculture of osteoblasts and bone marrow cells in the presence of HA resulted in decreased osteoclast differentiation. Cellular proliferation of osteoblasts and bone marrow cells in the presence of HA was significantly greater than in the absence of HA. However, adhesion of bone marrow cells was decreased by HA. The increased proliferation of osteoblasts and decreased number of attached bone marrow cells in the presence of HA lead to an imbalance between the number of these cells, resulting in suppressed osteoclast differentiation.
2014年度
Persistent ID (NDL): info:ndljp/pid/12071662
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2016-06-20
Format (IMT): application/pdf
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Periodical Title (URI): http://id.nii.ac.jp/1392/00000008/
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