A comprehensive mixture of tobacco smoke components retards orthodontic tooth movement via the inhibition of osteoclastogenesis in a rat model

Persistent ID (NDL): info:ndljp/pid/12071663

Material type: 博士論文

Author: ⻑家, 茉耶

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Publication date: 2015-03-06

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Tobacco smoke is a complex mixture of numerous components. Nevertheless, most experiments have examined the effects of individual chemicals in tobacco...

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Material Type: 博士論文
Title: A comprehensive mixture of tobacco smoke components retards orthodontic tooth movement via the inhibition of osteoclastogenesis in a rat model
Author/Editor: ⻑家, 茉耶
Author Heading: ⻑家, 茉耶
Publication Date: 2015-03-06
Publication Date (W3CDTF): 2015-03-06
Alternative Title: タバコ煙成分がラットの⻭の移動に及ぼす実験的研究
Degree grantor/type: 大阪歯科大学
Date Granted: 2015-03-06
Date Granted (W3CDTF): 2015-03-06
Dissertation Number: 甲第754号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第754号
Text Language Code: eng
Subject Heading: Acid Phosphatase
Animals
Bone Density Conservation Agents
Bone Resorption
Cell Line
Cells, Cultured
Isoenzymes
Nicotine
Osteoclasts
Rats
Smoke
Tobacco
Tooth Movement
Target Audience: 一般
Note (General): Tobacco smoke is a complex mixture of numerous components. Nevertheless, most experiments have examined the effects of individual chemicals in tobacco smoke. The comprehensive effects of components on tooth movement and bone resorption remain unexplored. Here, we have shown that a comprehensive mixture of tobacco smoke components (TSCs) attenuated bone resorption through osteoclastogenesis inhibition, thereby retarding experimental tooth movement in a rat model. An elastic power chain (PC) inserted between the first and second maxillary molars robustly yielded experimental tooth movement within 10 days. TSC administration effectively retarded tooth movement since day 4. Histological evaluation disclosed that tooth movement induced bone resorption at two sites: in the bone marrow and the peripheral bone near the root. TSC administration significantly reduced the number of tartrate-resistant acid phosphatase (TRAP)-positive osteoclastic cells in the bone marrow cavity of the PC-treated dentition. An in vitro study indicated that the inhibitory effects of TSCs on osteoclastogenesis seemed directed more toward preosteoclasts than osteoblasts. These results indicate that the comprehensive mixture of TSCs might be a useful tool for detailed verification of the adverse effects of tobacco smoke, possibly contributing to the development of reliable treatments in various fields associated with bone resorption.
2014年度
Persistent ID (NDL): info:ndljp/pid/12071663
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2016-06-20
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000007/
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