Coordinated effect of IL-17A and IL-27 on osteoclast differentiation of RANKL-stimulated RAW264.7 cells

• Material Type: 博士論文
• Title: Coordinated effect of IL-17A and IL-27 on osteoclast differentiation of RANKL-stimulated RAW264.7 cells
• Author/Editor: ⼤橋, 百加
• Author Heading: ⼤橋, 百加
• Publication, Distribution, etc.: 大阪歯科学会
• Publication Date: 2015-03-06
• Publication Date (W3CDTF): 2015-03-06
• Alternative Title: RANKL 刺激による RAW264.7 細胞の破⾻細胞分化における IL-17A と IL-27 の協調効果
• Degree grantor/type: 大阪歯科大学
• Date Granted: 2015-03-06
• Date Granted (W3CDTF): 2015-03-06
• Dissertation Number: 甲第747号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第747号
• Text Language Code: eng
• Subject Heading: Interleukin-17A (IL-17A); Interleukin-27 (IL-27); Osteoclast differentiation
• Target Audience: 一般
• Note (General): Orthodontic tooth movement is based on the response of biological tissue to mechanical loading. On both the compressed side and tensile side, stress is loaded onto cells by means of physical stimulation that causes cells to produce various cytokines that are involved in the promotion or suppression of osteoclast formation. During orthodontic tooth movement, alveolar bone resorption at the area of compression occurs through osteoclastic activity. In this study, we confirmed the coordinated effect of IL-17A and IL-27 on receptor activator of nuclear factor kB ligand (RANKL)-induced osteoclastogenesis, using RAW264.7 cells as osteoclast precursors. High expression of IL-17RC and IL27-Rα was detected on RAW264.7 cells, and this expression was not altered by the stimulation of RANKL for 24 h. A coordinated effect of IL-17A and IL-27 suppressed osteoclast differentiation from RAW264.7 cells treated with RANKL without reduction of cell proliferation. Furthermore, the phosphorylation of c-Jun-N-terminal kinase (JNK) stimulated with RANKL was inhibited by the coordinated effect of IL-17A and IL-27. These data suggest the possibility that the coordinated effect of IL-17A and IL-27 inhibited the phosphorylation of JNK which is involved in the suppression of RANKL-induced osteoclast differentiation in RAW264.7 cells. Our findings provide new insights into the mechanisms of osteoclastogenesis.; 2014年度
• Persistent ID (NDL): info:ndljp/pid/12071667; https://dl.ndl.go.jp/pid/12071667
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
• Date Created (W3CDTF): 2016-06-20
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://id.nii.ac.jp/1392/00000003/
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-08 再収集