Anticancer agent α-sulfoquinovosyl-acylpropanediol enhances the radiosensitivity of human malignant mesothelioma in nude mouse models

• Material Type: 博士論文
• ISSN: 1349-9157
• Title: Anticancer agent α-sulfoquinovosyl-acylpropanediol enhances the radiosensitivity of human malignant mesothelioma in nude mouse models
• Volume: 63 1
• Author/Editor: 稲益, 英子
• Author Heading: 稲益, 英子
• Publication, Distribution, etc.: Oxford University Press
• Publication Date: 2021-12-01
• Publication Date (W3CDTF): 2021-12-01
• Alternative Title: 抗がん剤α-SQAPはマウス悪性胸膜中皮腫モデルにおいて放射線感受性を増強する
• Periodical title: Journal of Radiation Research
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2021-12-01
• Date Granted (W3CDTF): 2021-12-01
• Dissertation Number: 甲医歯薬第1377号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医歯薬第1377号
• Text Language Code: eng
• Subject Heading: malignant pleural mesothelioma (MPM); radiosensitizer; hypoxia-inducible factor (HIF); sulfoquinovosyl-acylpropanediol (SQAP)
• Target Audience: 一般
• Note (General): Malignant pleural mesothelioma (MPM) is a highly malignant disease that develops after asbestos exposure. Although the number of MPM cases is predicted to increase, no effective standard therapies have been established. The novel radiosensitizer α-sulfoquinovosyl-acylpropanediol (SQAP) enhances the effects of γ-radiation in human lung and prostate cancer cell lines and in animal models. In this study, we explored the radiosensitizing effect of SQAP and its mechanisms in MPM. The human MPM cell lines MSTO-211H and MESO-4 were implanted subcutaneously into the backs and thoracic cavities of immunodeficient KSN/Slc mice, then 2 mg/kg SQAP was intravenously administered with or without irradiation with a total body dose of 8 Gy. In both the orthotopic and ectopic xenograft murine models, the combination of irradiation plus SQAP delayed the implanted human MSTO-211H tumor growth. The analysis of the changes in the relative tumor volume of the MSTO-211H indicated a statistically significant difference after 8 Gy total body combined with 2 mg/kg SQAP, compared to both the untreated control (P = 0.0127) and the radiation treatment alone (P = 0.0171). After the treatment in each case, immunostaining of the harvested tumors revealed decreased cell proliferation, increased apoptosis and normalization of tumor blood vessels in the SQAP- and irradiation-treated group. Furthermore, hypoxia-inducible factor (HIF) 1 mRNA and protein expression were decreased, indicating reoxygenation in this group. In conclusion, SQAP improved hypoxic conditions in tumor tissue and may elicit a radiosensitizing effect in malignant mesothelioma models.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1377号 学位授与年月日:令和3年12月1日; Author: Eiko Inamasu, Tomoshi Tsuchiya, Motohiro Yamauchi, Kodai Nishi, Katsuya Matsuda, Fumio Sugawara, Kengo Sakaguchi, Ryoichi Mori, Keitaro Matsumoto, Takuro Miyazaki, Go Hatachi, Ryoichiro Doi, Hironosuke Watanabe, Koichi Tomoshige, Naoki Matsuda, Yoshikazu Higami, Isao Shimokawa, Masahiro Nakashima, Takeshi Nagayasu; Citation: Journal of Radiation Research, 63(1), pp. 19–29; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2021-12-01); http://hdl.handle.net/10069/00041138
• DOI: info:doi/10.1093/jrr/rrab090; https://doi.org/info:doi/10.1093/jrr/rrab090
• Persistent ID (NDL): info:ndljp/pid/12154277; https://dl.ndl.go.jp/pid/12154277
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-03-06T04:54:00+09:00
• Date Created (W3CDTF): 2022-02-14
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://hdl.handle.net/10069/00041138
• Periodical Title (URI): http://hdl.handle.net/10069/00041264
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp