Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation

Persistent ID (NDL): info:ndljp/pid/12154552

Material type: 博士論文

Author: 田邊, 順一

Publisher: Japanese Association of Regenerative Dentistry

Publication date: 2013-12-25

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Adiponectin, an adipocyte-derived biologically active molecule, is a ∼30-kDa polypeptide containing an N-terminal signal sequence, variable domain, co...

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Material Type: 博士論文
Title: Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation
Author/Editor: 田邊, 順一
Author Heading: 田邊, 順一
Publication, Distribution, etc.: Japanese Association of Regenerative Dentistry
Publication Date: 2013-12-25
Publication Date (W3CDTF): 2013-12-25
Alternative Title: アディポネクチンコラーゲン様ペプチドの骨芽細胞分化促進作用
Degree grantor/type: 大阪歯科大学
Date Granted: 2013-12-25
Date Granted (W3CDTF): 2013-12-25
Dissertation Number: 乙第1582号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 乙第1582号
Text Language Code: eng
Subject Heading: adiponectin
collagen-like peptide
osteoblast
microarray
Target Audience: 一般
Note (General): Adiponectin, an adipocyte-derived biologically active molecule, is a ∼30-kDa polypeptide containing an N-terminal signal sequence, variable domain, collagen-like domain, and C-terminal globular domain. Previously we demonstrated that full-length adiponectin up-regulated the expression of genes related to osteoblastic differentiation, although the free globular domain down-regulated them. It was hypothesized that the collagen-like domain may be involved in osteoblastic differentiation, so we investigated the effect of novel synthesized collagen-like peptide on osteoblastic differentiation of murine pro-osteoblastic cells.Microarray analysis showed that the collagen-like peptide up-regulated the genes related to various signaling pathways involved in osteoblastic differentiation. In contrast, the globular domain suppressed the above genes and induced the expression of genes related to cell morphogenesis and neurological system processes. Real-time RT-PCR for osteocalcin clarified the microarray observation. Therefore, the novel synthesized collagen-like peptide had positive action on osteoblastic differentiation.
2013
Persistent ID (NDL): info:ndljp/pid/12154552
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-03-06T04:54:00+09:00
Date Created (W3CDTF): 2016-07-01
Format (IMT): application/pdf
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Periodical Title (URI): http://id.nii.ac.jp/1392/00000063/
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