Activation of microglial cells in the trigeminal subnucleus caudalis evoked by inflammatory stimulation of the oral mucosa

Persistent ID (NDL): info:ndljp/pid/12154556

Material type: 博士論文

Author: 黄, 宏智

Publisher: Editorial Board of Okajimas Folia Anatomica Japonica

Publication date: 2013-09-25

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: To study the inflammatory hyperalgesia induced by an acute noxious stimulation of oral mucosa with 5% formalin (5%FOR), we performed an immunohistoche...

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Material Type: 博士論文
Title: Activation of microglial cells in the trigeminal subnucleus caudalis evoked by inflammatory stimulation of the oral mucosa
Author/Editor: 黄, 宏智
Author Heading: 黄, 宏智
Publication, Distribution, etc.: Editorial Board of Okajimas Folia Anatomica Japonica
Publication Date: 2013-09-25
Publication Date (W3CDTF): 2013-09-25
Alternative Title: 口腔粘膜への侵害刺激により誘発される三叉神経脊髄路核尾側亜核内マイクログリアへの活性化
Degree grantor/type: 大阪歯科大学
Date Granted: 2013-09-25
Date Granted (W3CDTF): 2013-09-25
Dissertation Number: 乙第1579号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 乙第1579号
Text Language Code: eng
Subject Heading: microglia
Vc
nociception
Target Audience: 一般
Note (General): To study the inflammatory hyperalgesia induced by an acute noxious stimulation of oral mucosa with 5% formalin (5%FOR), we performed an immunohistochemical study on the expression of TNFá in the intermolar region of the dorsal lingual eminence (IDLE), and Iba1 and phosphorylated (phospho)- p38 MAPK involved with central nervous system microglial activation in the trigeminal subnucleus caudalis (Vc). The present study observed significantly increased expression of TNFá at either 1h or 24h of 5%FOR nociception, as well as sustained TNFá immunoreactivity in the IDLE. On the other hand, at either 1h or 24h 5%FOR nociception, Iba1- immunoreactive (IR) cells in the Vc were significantly increased after inflammatory stimulation of the IDLE; the increase was more evident at 24h 5%FOR nociception. By using the double-label immunofluorescence technique, the findings in particular demonstrated a significant increase in the number of phospho-p38 MAPK- and Iba1-IR coexpressed cells in the Vc at 24h 5%FOR nociception. The results suggest that 24h persistent microglial activation in subnuclei zonalis and gelatinosus of the Vc is evoked by 5%FOR noxious stimulation of the IDLE oral mucosa, thereby the present study indicates that the MAPK expression plays important roles in microglial activation related with central sensitization and inflammatory hyperalgesia.
2013
Persistent ID (NDL): info:ndljp/pid/12154556
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-03-06T04:54:00+09:00
Date Created (W3CDTF): 2016-06-29
Format (IMT): application/pdf
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Periodical Title (URI): http://id.nii.ac.jp/1392/00000059/
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