Effect of VCAM-1 on the Differentiation into Osteoclast
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- Material Type
- 博士論文
- Author/Editor
- 林, 寛
- Author Heading
- Publication, Distribution, etc.
- Publication Date
- 2014-03-07
- Publication Date (W3CDTF)
- 2014-03-07
- Alternative Title
- 破骨細胞分化に及ぼすVCAM-1の影響
- Degree Grantor
- 大阪歯科大学
- Date Granted
- 2014-03-07
- Date Granted (W3CDTF)
- 2014-03-07
- Dissertation Number
- 甲第733号
- Degree Type
- 博士（歯学）
- Conferring No. (Dissertation)
- 甲第733号
- Text Language Code
- eng
- Subject Heading
- Target Audience
- 一般
- Note (General)
- In Orthodontic therapy, osteoclast precursors such as monocytes and macrophages migrate from vessels into the periodontium and then differentiate into osteoclasts, causing bone resorption. Focal adhesion kinase (FAK) is a 125-kDa non-receptor type tyrosine kinase that localizes to focal adhesions. FAK is involved in osteoclastic bone resorption. Vascular cell adhesion molecule-1 (VCAM -1) is bound to VLA-4(very late antigen-4) which is kind of the α<sub>4</sub> β1-integrin, and recruits monocytic osteoclast progenitors and elevates local osteoclast activity.In our present study we focused on VCAM-1 /α<sub>4</sub> integrin-mediated the differentiation into osteoclasts and found that this type of the differentiation was mediated through FAK. RAW267.4 expressed both α<sub>4</sub> integrins, and it was reported that expression of α<sub>4</sub> integrin and its counterreceptor, VCAM-1, was not enhanced in response to receptor activator of NF-B ligand (RANKL). Neutralizing antibodies against integrin α4 effectively inhibit the differentiation into osteoclasts and phosphorylation of FAK. These findings establish VCAM-1 regulate the differentiation into osteoclasts in bone.2013機関リポジトリ記載の権利情報: CC BY-NC-ND
- Persistent ID (NDL)
- info:ndljp/pid/12154568
- Collection
- Collection (Materials For Handicapped People:1)
- Collection (particular)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- Acquisition Basis
- 博士論文（自動収集）
- Date Accepted (W3CDTF)
- 2022-03-06T04:54:00+09:00
- Format (IMT)
- application/pdf
- Access Restrictions
- 国立国会図書館内限定公開
- Service for the Digitized Contents Transmission Service
- 図書館・個人送信対象外
- Availability of remote photoduplication service
- 可
- Periodical Title (URI)
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館デジタルコレクション