SOX4 expression is closely associated with differentiation and lymph node metastasis in oral squamous cell carcinoma

Persistent ID (NDL): info:ndljp/pid/12154581

Material type: 博士論文

Author: 渡辺, 昌広

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Publication date: 2014-03-07

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: SOX4 is a member of the SOX family of transcription regulators. In recent years, SOX4 was shown to be overexpressed in cancers of various organs and r...

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Material Type: 博士論文
Title: SOX4 expression is closely associated with differentiation and lymph node metastasis in oral squamous cell carcinoma
Author/Editor: 渡辺, 昌広
Publication Date: 2014-03-07
Publication Date (W3CDTF): 2014-03-07
Alternative Title: 口腔扁平上皮癌におけるSOX4の発現と分化およびリンパ節転移に関する解析
Degree grantor/type: 大阪歯科大学
Date Granted: 2014-03-07
Date Granted (W3CDTF): 2014-03-07
Dissertation Number: 甲第717号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第717号
Text Language Code: eng
Subject Heading: Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
Chemoradiotherapy, Adjuvant
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Lymphatic Metastasis
Male
Middle Aged
Mouth Neoplasms
Neoadjuvant Therapy
SOXC Transcription Factors
Sex Factors
Statistics, Nonparametric
Note (General): SOX4 is a member of the SOX family of transcription regulators. In recent years, SOX4 was shown to be overexpressed in cancers of various organs and related to epithelial-mesenchymal transition, which is a metastatic factor. This study was the first to investigate correlations between SOX4 expression levels and the clinicopathologic factors of oral squamous cell carcinoma (OSCC). We analyzed SOX4 expression levels in 50 patients with OSCC using immunohistochemistry. All samples expressed the SOX4 protein and elevated SOX4 expression was significantly correlated with gender, T status, and stage levels. The expression level of SOX4 in primary foci of poorly differentiated OSCC was higher than that of well differentiated OSCC, which indicated that SOX4 expression is associated with the differentiation of OSCC. However, regardless of the differentiation level in the primary focus, SOX4 expression levels were found to be very high in the metastatic focus. Furthermore, SOX4 expression in metastatic foci was significantly suppressed by neoadjuvant therapy. These results indicate that undifferentiated OSCC cells expressing SOX4 are more likely to metastasize and neoadjuvant therapy including chemoradiation therapy may have some effect in metastatic prevention.
2013
元資料の権利情報 : CC BY-NC-ND
Persistent ID (NDL): info:ndljp/pid/12154581
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Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-03-06T04:54:00+09:00
Date Created (W3CDTF): 2016-06-27
Format (IMT): application/pdf
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000033/
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