The middle rectal artery detected by contrast-enhanced magnetic resonance imaging predicts lateral lymph node metastasis in lower rectal cancer. 8

• Material Type: 博士論文
• Title: The middle rectal artery detected by contrast-enhanced magnetic resonance imaging predicts lateral lymph node metastasis in lower rectal cancer.
• Volume: 36 8
• Author/Editor: Iwasa, Yosuke; Koyama, Fumikazu; Marugami, Nagaaki; Kuge, Hiroyuki; Nakamoto, Takayuki; Obara, Shinsaku; Nishiwada, Satoshi; Takei, Takeshi; Sadamitsu, Tomomi; Yamauchi, Satoshi; Kichikawa, Kimihiko; Sho, Masayuki
• Author Heading: Iwasa, Yosuke; Koyama, Fumikazu; Marugami, Nagaaki; Kuge, Hiroyuki; Nakamoto, Takayuki; Obara, Shinsaku; Nishiwada, Satoshi; Takei, Takeshi; Sadamitsu, Tomomi; Yamauchi, Satoshi; Kichikawa, Kimihiko; Sho, Masayuki
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2021-08; 36 8
• Publication Date (W3CDTF): 2021-08
• Alternative Title: 下部直腸癌における側方リンパ節転移に関して、造影MRI で描出される中直腸動脈の転移予測因子に関する検討
• Periodical title: International journal of colorectal disease
• Pages: 1677-1684
• ISSN (Periodical Title): 01791958
• Degree Grantor: 奈良県立医科大学
• Date Granted: 2021-12-21
• Date Granted (W3CDTF): 2021-12-21
• Dissertation Number: 乙第1512号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第1512号
• Text Language Code: eng
• Subject Heading: Rectal cancer; Lateral lymph node metastasis; Magnetic resonance imaging; Middle rectal artery
• Target Audience: 一般
• Note (General): type:Thesis; Purpose: Lateral lymph node (LLN) metastasis is one of the leading causes of local recurrence in patients with lower rectal cancer. Unfortunately, no diagnostic biomarkers are currently available that can predict LLN metastasis preoperatively. Accordingly, we investigated the relationship between the middle rectal artery (MRA) identified by contrast-enhanced magnetic resonance imaging (ceMRI) and LLN metastases. Methods: Data from 102 patients with lower rectal cancer who underwent surgery, and were evaluated by preoperative ceMRI, between 2008 and 2016 were reviewed retrospectively. Two expert radiologists evaluated the MRA findings. The diagnostic performance of MRA for LLN metastasis was evaluated by a multivariate analysis with conventional clinicopathological factors. Results: The MRA was detected in 67 patients (65.7%), including 32 (31.4%) with bilateral MRA and 35 (34.3%) with unilateral MRA. The tumor size, presence of the MRA, and clinical LLN status were significantly correlated with LLN metastasis. A multivariate analysis demonstrated that the presence of MRA (P = 0.045) and clinical LLN status (P = 0.001) were independent predictive factors for LLN metastasis. Furthermore, the sensitivity and negative predictive value of MRA for LLN metastasis were 95% and 97.1%, respectively. Conclusion: We successfully demonstrated that MRAs could be clearly detected by ceMRI, and the presence of MRA robustly predicted LLN metastasis in patients with lower rectal cancer, highlighting its clinical significance in the selection of more appropriate treatment strategies. Trial registration: Trial registration number: retrospectively registered 2126 Trial registration date of registration: August 23, 2019.; 博士（医学）・乙第1512号・令和3年12月21日; © 2021. The Author(s).Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.; identifier:International journal of colorectal disease Vol.36 No.8 p.1677-1684 (2021 Aug); identifier:01791958; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3957; identifier:International journal of colorectal disease, 36(8): 1677-1684
• Persistent ID (NDL): info:ndljp/pid/12219036; https://dl.ndl.go.jp/pid/12219036
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-04-04T15:10:33+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): https://doi.org/10.1007/s00384-021-03887-w
• Periodical Title (URI): http://hdl.handle.net/10564/3957
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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